Oliver Speck

University Teacher

Prof. Dr. rer. nat. habil. Oliver Speck

Faculty of Natural Sciences
Institut for Physics
Leipziger Str. 44, 39120 Magdeburg, H65-393
Vita
1993-1994 Diploma Thesis in Physics, University Hospital Freiburg (FRG), MR Center,
and University of Freiburg (FRG), Department of Physics
04/1994-04/1997 Ph.D. in Physics University Hospital Freiburg (FRG), MR Center,
and University of Freiburg, Department of Physics
04/1997-10/1997 Research Associate
Director: J. Hennig, Ph.D.
University Hospital Freiburg (FRG), Dept. of Radiology, MR Center
11/1997-10/1999 Research Associate
Director: T. Ernst, Ph.D. and L. Chang, M.D.
UCLA-Harbor UCLA Research & Education Inst., Torrance, CA
11/1999-12/2005 Staff Research Associate (deputy head of section of MR-physics)
Head of Emmy-Noether-Group
Director: J. Hennig, Ph.D.
University Hospital Freiburg (FRG), Dept. of Radiology, MR Center
09/2005 Habilitation in Medical Physics at the Department of Diagnostic Radiology,
University of Freiburg
01/2006-10/2006 Research Director
University Hospital Freiburg (FRG), Dept. of Diagnostic Radiology
since 11/2006 Prof. for Biophysics and Director of the Dept. Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg
Reviewer for Scientific Journals and societies
  1. Magnetic Resonance in Medicine (Deputy Editor)
  2. International Society for Magnetic Resonance in Medicine
  3. European Society for Magnetic Resonance in Medicine and Biology
    • Concepts in Magnetic Resonance
    • NeuroImage
    • Solid State Nuclear Magnetic Resonance
    • Swiss National Science Foundation
  4. Deutsche Forschungsgemeinschaft (German Research Foundation)
  5. Dutch Technology Foundation

 

Grants

Current projects

A4IM - Affordable low-field MRI reference system
Duration: 01.09.2023 bis 31.08.2026

Das Gesamtziel dieses Projekts besteht darin, innerhalb des EURAMET-Netzwerks kostengünstige, quelloffene Niederfeld-MRT-Systeme zu entwickeln, inklusive Hardwarekomponenten, Datenerfassung und Bildrekonstruktion, die reproduzierbar, vollständig dokumentiert und messtechnisch charakterisiert sind.
Die spezifischen Ziele des Projekts sind:
1. Entwurf, Entwicklung und Evaluierung mobiler (<300 kg), kostengünstiger (<50 k€) und vollständig reproduzierbarer Niederfeld-MRT-Referenzsysteme (statisches Hauptfeld B0 ≈ 50 mT), die für die Bildgebung des menschlichen Kopfes und der Extremitäten geeignet sind.
2. Entwicklung modellbasierter Bildrekonstruktionsverfahren unter Verwendung der Referenzsysteme in Ziel 1.
3. Bewertung der klinischen Eignung der entwickelten Niederfeld-MRT-Referenzsysteme durch standardisierte Tests, an denen klinische Radiologen teilnehmen, um die Bildgebungsleistung an verschiedenen Standorten zu beurteilen.
4. Ermöglichung der Translation der im Rahmen des Projekts entwickelten Technologie und Messinfrastruktur durch Anbieter (z. B. akkreditierte Labors, Gerätehersteller), normenentwickelnde Organisationen (z. B. IEC TC 62/SC 62B) und Endnutzer (z. B. die klinische Gemeinschaft).

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SFB1315 B06
Duration: 01.07.2022 bis 30.06.2026

The proposed project aims at understanding how systems level hippocampally-related functional connectivity as well as cortico-cortical microstructure changes indicative of memory engrams develop during memory consolidation. We will use a novel and unique 7T connectome MRI for humans to achieve the highest to-date possible resolution for functional and diffusion magnetic resonance imaging (MRI). This will allow imaging of the emergence of cortico-cortical connectivity and engram-related plasticity in a layer-specific manner in early and late stages of memory consolidation, thereby narrowing the gap between an animal-led and human-led understanding of memory consolidation. As neuromodulatory inputs related to more or less salient memory events are one of the most prominent drivers of the long-term stability of memories we will additionally investigate how a stronger involvement of neuromodulatory and ‘saliency-processing structures’ affects memory consolidation. Moreover, we will assess whether semantic congruency affects the time course of dynamics in the memory consolidation network or memory engram formation.

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Gerätezentrum "Magdeburg UHF-MR" Core Facility
Duration: 01.05.2023 bis 30.04.2026

The Magdeburg UHF-MR Core Facility will provide 7T MRI technology and methodology that is unique in Europe. As the first centre in Europe, the Magdeburg UHF-MR Core Facility will operate two human 7T MRI systems, one state-of-the-art 7T MRI and one 7T “Connectome” MRI with unprecedented gradient performance. Users are scientists mainly from the field of basic, applied and clinical neuroscience from different institutions in Magdeburg as well as external researchers.
The main goal is to establish and provide the best possible infrastructure, measurement methods and technologies together with professional support for all imaging researchers. The project is structured into 5 work packages:
- develop and maintain cutting edge methodology
- establish methods to ensure and monitor highest data quality
- provide training and imaging support to the users
- develop and provide digital research data management tools
- establish the organizational structure and administrative procedures
The unique 7T hardware capabilities and the available unique methodological expertise and longest standing 7T MRI experience in Magdeburg form the basis for new superb research opportunities with highest level support and service for the users.

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Forschungscampus STIMULATE 2. Förderphase - Teilvorhaben OvGU, Focus-Bereich: iMRI-Solutions - FKZ: 13GW0473A
Duration: 01.10.2020 bis 30.09.2025

Vorhabengegenstand ist der Bereich der Onkologie, mit dem Fokus auf ablative Therapien und Bildführung mittels MRT und CT mit dem Ziel der kurativen Behandlung von malignen Erkrankungen.

Die Zielsetzung besteht darin, die bildgeführten Interventionen einfacher, schneller, kostengünstiger, schonender und kurativ zu machen, sodass sie in der breiten klinischen Routine Einzug halten. Dazu wurden drei wesentliche medizintechnische Herausforderungen identifiziert, die innerhalb von vier Leit- bzw. Querschnittsthemen - iMRI Solutions, iCT Solutions, Immunoprofiling und Computational Medicine - gelöst werden sollen.

  • Kurative Therapie: Heutzutage haben die Interventionen primär eine palliative Bedeutung. In Analogie zur vollständigen chirurgischen Entfernung bösartigen Gewebes (R0-Resektion) strebt STIMULATE die komplette Abtragung der Läsion (A0-Ablation) und damit die Heilung des Patienten an. Die anvisierten Zielorgane insbesondere Leber - aufgrund der komplexen Gefäßversorgung - sowie Lunge - aufgrund der Pneumothorax- bzw. Luftemboliegefahr - beinhalten erhebliche Herausforderungen bei der Planung und Durchführung bildgeführter ablativer Therapien.
  • Lokale und systemische Überwachung: Die heutigen ablativen Verfahren stellen rein mechanistische Ansätze dar. Im Querschnittsthema Immunoprofiling berücksichtigtSTIMULATE erstmals - in einem translationalen Ansatz der Grundlagenforschung - die lokalen und systemischen Wechselwirkungen verschiedener lokoregionaler Therapieverfahren zur Überwachung und Prognose der kurativen A0-Therapie.
  • Dedizierte Bildgebungssysteme: Gegenwärtig werden für Interventionen MRT- und CT-Geräte eingesetzt, welche für die Diagnostik optimiert wurden und nur durch behelfsmäßige Zusatzausstattungen im OP eingesetzt werden können. Mit der in STIMULATE vorhandenen Expertise im Bereich der Bildgebung wird angestrebt, in den Leitthemen iMRI-Solutions und iCT-Solutions, spezielle interventionelle Geräte zu erforschen.

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DZPG: Deutsches Zentrum für Psychische Gesundheit FKZ: BMBF 01EE2305D
Duration: 01.07.2023 bis 30.06.2025

Die schwerwiegenden individuellen und gesamtgesellschaftlichen Folgen psychischer Erkrankungen sind Ausgangspunkt, und deren nachhaltige Beeinflussung das zentrale Ziel des Deutschen Zentrums für Psychische Gesundheit (DZPG). Das BMBF hat mit dem DZPG ein weiteres Gesundheitszentrum etabliert, das mit seinem Fokus auf translationale Gesundheitsforschung sicherstellen wird, dass innovative Präventions-, Diagnose- und Therapieverfahren für psychische Erkrankungen generiert und zeitnah in die Regelversorgung übersetzt werden. Darüber hinaus wird das DZPG Lösungen für inakzeptable gesellschaftliche Ungleichheiten in der Versorgung von Menschen mit psychischen Erkrankungen erarbeiten. Diese gibt es sowohl in der „horizontalen Perspektive“, so z.B. zwischen den ländlichen und städtischen Lebenswelten, als auch in „vertikalen Kontexten“ z.B. bezüglich vulnerabler Gruppen. Um diese Versorgungslücken in der Erwachsenenbevölkerung und bei Kindern und Jugendlichen zu schließen, wird das DZPG ein ambitioniertes translationales Forschungsprogramm auflegen, das die Förderung von psychischer Gesundheit und Resilienz in den Mittelpunkt stellen, die gesellschaftliche Wahrnehmung psychischer Erkrankungen verbessern und die durch psychische Erkrankungen verursachten Belastungen in den nächsten 15 Jahren reduzieren wird. Hauptpartner im DZPG sind die sechs Standorte Berlin/Potsdam, Bochum/Marburg, Halle/Jena/Magdeburg, Mannheim/Heidelberg/Ulm, München/Augsburg, Tübingen und die Repräsentanten des Zentrumsrates. Der Zentrumsrat ist der Zusammenschluss der Betroffenen und Angehörigen. Die übergreifenden Ziele des DZPG sind auch für den Standort Halle/Jena/Magdeburg maßgeblich, zudem folgende Institutionen zählen: Universitätsklinikum Jena (UKJ), Friedrich-Schiller-Universität Jena (FSU), Martin-Luther-Universität Halle-Wittenberg (MLU), Otto-von- Guericke-Universität Magdeburg (OvGU), Universitätsklinikum Magdeburg (UMMD), Leibniz-Institut für Neurobiologie Magdeburg (LIN).

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“Quantification of perivascular spaces in neuropsychiatric long-COVID/post-COVID (LC/PC) syndrome as a biomarker for persisting perivascular inflammation and disease trajectories (JE2/TP5)”
Duration: 01.07.2023 bis 30.06.2025

Psychiatric symptoms such as fatigue, depression and cognitive impairment are highly prevalent among long-COVID/post-COVID (LC/PC) patients. Among the mechanisms of persistent systemic and intracerebral inflammation proposed to cause LC/PC symptoms, evidence supports the perivascular inflammation hypothesis: SARS-CoV-2 damaging cerebral microvasculature and impeding brain clearance due to its destructive effects on the endothelium. Preliminary results revealed a significant correlation between enlarged perivascular spaces (EPVS) in the basal and symptoms of fatigue in LC/PC patients. We hypothesize that EPVS severity could be dynamically associated with clinical symptom development in LC/PC and will study EPVS dynamics over time to test for a mediating role of EPVS load on psychiatric and cognitive symptoms.

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ACCESSORY KIT FOR INTERVENTIONAL PROCEDURES USING MAGNETIC RESONANCE IMAGING
Duration: 05.01.2023 bis 04.01.2025

Abstrakt

An accessory kit is provided for interventional procedures using a magnetic resonance imaging scanner. The accessory kit includes a patient support and an electrical connection adapter. The patient support has a first end proximal and a second end distal to the scanner. The distal end is configured to create a space to accommodate a clinician, such as narrowing of the distal end or at least one cutout on a side of the distal end. The electrical connection adapter interfaces with the scanner and a scanner table. The accessory kit is configured so that when the proximal end is extended into the scanner bore, the distal end extends outside the bore. The narrowed width and/or cutout(s) of the exposed distal end and the extended gap between the scanner and scanner table create space on at least one side of the patient support that a clinician may use to access a patient.

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Human imaging at meso-scale
Duration: 01.01.2021 bis 31.12.2024

It is known from animal work that most mechanisms limiting neural resources manifest at the level of brain microstructure and influence brain functions at different hierarchical levels, such as brain macrostructure, neuronal networks, and behavioural phenotypes. Current research on neural resources in humans, however, often lacks a mechanistic level of explanation due to missing technology and/or methodological expertise needed to describe neuronal changes at the meso-scale (i.e. at the level of cortical layers or neuronal ensembles). This hinders knowledge transfer from mechanistic insights at the micro-scale gained in animal research to macro-scale human brain models and interventions. The CRC initiative has the overall goal to systematically investigate neural resources at the micro-, meso-, and macro-scale by taking an interdisciplinary and multi-scale approach and to link changes in the functional and structural architecture of cortical and subcortical micro-circuits to behavioural performance and cognitive interventions. Technological advancements in meso-scale brain imaging, meso-scale data modelling, and multi-modal and multi-scale data interaction can bridge this gap. The aim of Z02 is to develop and test novel technologies using ultra-high resolution 7 Tesla magnetic resonance imaging (7T MRI) for wider applications in human subjects and primates and to provide them to the researchers of the CRC projects by ensuring (i) usage of appropriate and state-of-the-art MR-sequences that offer reproducible and optimised data quality and (ii) computational tools and analysis pipelines for multi-modal and multi-scale data modelling within and across individuals. Z02 has the overarching goal of modelling the human cortex in three dimensions, that is, both in plane at the cortical surface (dimensions 1&2) and in cortical depth (dimension 3, cf. Kuehn & Sereno 2018, Fig. 1). This approach extends the frequently applied localisation of function in cortical regions, e.g. Brodmann areas, or more advanced and ambitious columnar mapping, to a novel level of detail relevant for cognitive processes (e.g., Larkum et al. 2018). This will allow the CRC projects to target research questions on neural resources in a novel yet undiscovered dimension, while at the same time enabling Magdeburg to maintain its leading position for human brain imaging in Europe.

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Zusammenarbeit auf dem Gebiet der physikalischen-technischen MR-Entwicklung, Kooperation mit SIEMENS Healthcare
Duration: 01.12.2015 bis 31.12.2024

Die Erforschung, Entwicklung und klinische Erprobung neuer MR-Techniken zur Bildgebung und Spektroskopie erfordert eine enge Zusammenarbeit zwischen SIEMENS und physikalisch-technischen und klinischen Partnern und Anwendern. SIEMENS und die UNIVERSITÄT als Anwender sind daran interessiert, im Rahmen dieses Vertrages zusammenzuarbeiten.

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Vascular resistance and resilience in ALS - an ultrahigh-resolution 7T MRI study of the motor cortex
Duration: 01.10.2022 bis 30.09.2024

Die Amyotrophe Lateralsklerose (ALS) ist eine rasch progrediente neuromuskuläre Erkrankung mit Degeneration der Pyramidenzellen des Motorkortex‘ (M1). Die Ursache der sporadischen Form der ALS ist unvollständig geklärt; die Behandlung der Erkrankung rein supportiv, kausale Therapieansätze fehlen. Obwohl viele der betroffenen Patienten innerhalb von 3 bis 5 Jahren nach Diagnosestellung an einer Insuffizienz der Atemmuskulatur versterben, sind Krankheitsverlauf und Prognose im Einzelfall äußerst heterogen. Dieses wird anhand individueller motorischer Phänotypen, langer Krankheitsverläufe oder einer möglichen Regredienz motorischer Funktionsverluste deutlich. Im vorgelegten Antrag hypothetisieren wir, dass dieser Heterogenität eine variable Gefäßversorgung des Motorkortex‘ zugrunde liegt, die einer M1-Pyramidenzelldegeneration ("resistance") oder deren motorischen Folgeerscheinungen ("resilience") entgegenwirkt. Zur Beantwortung der Fragestellung wird prospektiv eine selektierte ALS-Kohorte von 20 Patienten sowie 20 alters- und geschlechtsangepasste Kontrollprobanden mittels 7 Tesla Ultra-Hochfeld-Magnetresonanztomographie (MRT) unter Verwendung einer Angiographie (ToF-MRA) und anatomischer Sequenzen (MPRAGE) untersucht. Visuell werden zwei vaskuläre M1-Muster, jeweils separat für die Äste der A. cerebri anterior (medialer Motorkortex) und die der A. cerebri media (lateraler Motorkortex) unterschieden: singulär, d.h. eine M1-Versorgung durch die terminalen kortikalen kleinen Arterien eines Astes, oder dual, d.h. durch die terminalen kortikalen kleinen Arterien von zwei Ästen. Es wird angenommen, dass ein duales vaskuläres Muster aufgrund überlappender Perfusionsterritorien beider Äste einer Pyramidenzelldegeneration oder deren motorischen Folgeerscheinungen entgegenwirkt. Zur quantitativen Analyse wird das "vessel distance mapping" angewandt, welches jedem Voxel die Distanz zu den untersuchten Arterien zuordnet, woraus sich eine Approximation der Perfusionsterritorien ableiten lässt. Anhand von Mediationsmodellen werden direkte Effekte von vaskulärem Muster und Perfusionsterritorien auf die Pyramidenzelldegeneration (erfasst anhand der M1-Kortexdicke) untersucht, und, inwiefern deren Schwere den Einfluss von vaskulärem Muster und Perfusionsterritorien auf die motorische Funktion (global und körperteilspezifisch) zum Zeitpunkt des Einschluss-MRTs und im Langzeitverlauf vermittelt. Vaskuläre Muster könnten als neue Variable die phänotypische Variabilität der ALS erklären helfen, die auch translational im klinischen Alltag als zusätzlicher Aspekt für eine individualisierte Patientenberatung bezüglich Krankheitsverlauf und Prognose heranziehbar wäre. Die zerebrale Vaskulatur stellt potentiell modifizierbares Gewebe dar, dessen Funktionalität sowohl medikamentös als auch anhand von Lebensführung beeinflusst werden kann. Ein "vaskulärer Therapieansatz" könnte in dem Sinne zu vollkommen neuen Strategien in der Prävention und Behandlung der ALS führen.

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Vascular resistance and resilience in ALS – an ultrahigh-resolution 7T MRI study of the motor cortex
Duration: 01.10.2022 bis 30.09.2024

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neuromuscular disorder hallmarked by pyramidal cell degeneration of the motor cortex (M1). The underlying causes of sporadic ALS remain largely unknown, limiting its treatment options to supportive measures without any causal therapies. Even though many patients die within 3 to 5 years through respiratory insufficiency, individual ALS disease course and prognosis are highly variable. This is mirrored by distinct motor phenotypes, very long survival times of up to 10 years, and cessation or even reversal of disease progression in individual patients.In the presented proposal we hypothesize that a root cause of clinical ALS heterogeneity is a variable vascular supply of the motor cortex, which mitigates M1 pyramidal cell degeneration (“resistance”) or its impact on motor function (“resilience”). To address this question, we will prospectively examine a selected cohort of 20 ALS patients and 20 age- and sex-matched controls that will undergo 7 Tesla ultra-high field magnetic resonance imaging (MRI) applying angiographic (ToF-MRA) and anatomical sequences (MPRAGE). By visual rating two vascular patterns of M1 supply will be distinguished for the branches of the anterior cerebral artery (medial motor cortex) and middle cerebral artery (lateral motor cortex), respectively: a “single supply” pattern in which the M1 supply is provided by the terminal cortical arteries of one single branch only, or a “double supply” pattern, in which two branches feed the supplying terminal cortical arteries. We assume that a “double supply” pattern results in overlapping perfusion territories of both branches which mitigate M1 pyramidal cell degeneration or its impact on motor function. For quantitative analysis vessel distance mapping will be applied, which assigns each non-vessel voxel the distance to each of the examined arteries and thus consequently allows an approximation of the branches’ perfusion territories. Based upon mediation models the direct effects of the vascular supply patterns and perfusion territories on pyramidal cell degeneration (studied using M1 cortical thickness, global and body-part specific) will be assessed, as well as whether their severity mediates the influence of vascular supply patterns and perfusion territories upon motor function (global and body-part specific), both, at the time of the baseline MRI and longitudinally.Vascular patterns could serve as a new marker to explain the phenotypic variability in ALS, which might prove useful as an additional aspect for an individualized patient counseling regarding disease course and prognosis. Additionally the cerebral vasculature is potentially “dynamic” tissue, whose functionality can be modified through lifestyle and certain drugs. A “vascular approach to therapy” might lead to new avenues in the prevention and treatment of ALS.

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SFB-TRR 287 A2: 3D-Measurements in dense granular assemblies using hyperpolarised Magnetic Resonance Imaging
Duration: 01.07.2020 bis 30.06.2024

Research areas
Biomedical Technology and Medical Physics (205-32)
Biomedical System Technology (407-06)

Due to the limited accessibility of the bulk material to direct detection methods, often only integral flow quantities can be measured at the inlet and outlet of packed bed reactors. The exact understanding of the processes inside these technical systems is, thus, just as difficult as the system design with regard to energy efficiency and product quality. Furthermore, predictions from simulations cannot be experimentally validated in detail. Therefore, in project A2 the three-dimensional (3D) velocity field of the gas flow will be first measured in the reference configuration of the CRC/TRR with spherical and complex shaped particles by means of hyperpolarised phase contrast magnetic resonance imaging (pc-MRI). Three-dimensional, temporally and spatially resolved flow maps of the entire gas volume will be generated. These flow field data are essential and form the basis for the further understanding of the homogeneous and heterogeneous chemical reaction rates in particle beds. Sensors or tracer particles, which in turn can perturb the flow and particle movement, are not required. Optical access is also not necessary and arbitrary geometries are possible. The high flexibility of pc-MRI allows adaptations of the measurement to the requirements, e.g. regarding the sample volume (up to about 40 x 40 x 40 cm in commercial MRI) and the spatial (approx. 1 millimetre) or temporal resolution (approx. 1/10 second). With established MRI methods, usually only liquids can be detected due to their favourable physical properties with regards to generation of magnetisation (also called spin polarisation) and its life-time (relaxation properties). In this project, the transition to gaseous media is made possible by the application of highly innovative hyperpolarisation techniques. With this, the comprehensive three-dimensional, quantitative measurement of gas flow fields in complex geometries of non-transparent particle beds will be possible for the first time. Therefore, in addition to hyperpolarisation of the gas, MRI flow measurement methods for hyperpolarised magnetisation must be established. In addition, the development of materials and measurement setups is required that support the use of hyperpolarised gases without interference with the high spin polarisation. A2 will, therefore, build a continuous flow Xenon hyperpolariser with sufficient flow and polarisation level for fast and accurate MRI detection of gas (WP 1), a Xe-coil for Xe-MRI (WP 2), select and characterise proper materials for building an MR-compatible reference experiment (WP 3), extend a table to MR system for Xe-capability (WP 4), develop 3D pc-MRI flow measurement method for the application in hyperpolarised gas systems (WP 5) and measure and process flow data from the reference configuration (WP 6) to be provided to the simulation projects and to be compared to the other experimental methodology.

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Completed projects

7 Tesla Connectome Magnetresonanztomograph
Duration: 01.02.2020 bis 31.03.2023

Ein 7 Tesla Magnetresonanztomograph (MRT) mit einzigartigem Leistungsvermögen, welches weit über das vorhandene 7 Tesla MRT hinausgeht, wird als Forschungsinfrastruktur in Magdeburg mit Hilfe des Forschungsprogrammes Sachsen-Anhalt Wissenschaft/Infrastruktur etabliert. Diese Forschungsinfrastruktur kombiniert die ultra-hohe Magnetfeldstärke und damit Sensitivität von 7 Tesla MRT mit den stärksten Bildgebungsgradienten ("Connectome Gradienten"), welche die Informationskodierung bewirken. Die Gradienten werden mindestens die dreifache Stärke und doppelte Geschwindigkeit des vorhandenen Systems erreichen. Dies ist die konsequente Fortführung und Erweiterung der Bildgebungsinfrastruktur für die Neurowissenschaften und sichert Magdeburg eine Führungsposition in diesem Forschungsfeld.

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SFB 1315 - Teilprojekt B06 - Mechanismen und Störungen der Gedächtniskonsolidierung: Von Synapsen zur Systemebene
Duration: 01.01.2018 bis 31.12.2022

Im Teilprojekt B06 untersuchen wir, welche funktionellen Netzwerke im Gehirn die Festigung (Konsolidierung) neu gelernter Informationen regulieren. Wir wollen untersuchen, wie die Dopamin-Freisetzung in der Ruhephase nach dem Lernen mit der langfristigen Gedächtniskonsolidierung und deren Abnahme im Alter in Verbindung steht. Um diese Ziele erreichen zu können, werden wir multi-modale funktionelle Magnetresonanztomographie (fMRI) und molekulare Bildgebung (Positronen-Emissions-Tomographie - PET) mit Hilfe des in Magdeburg neu verfügbaren simultanen MRT und -PET Gerätes nutzen. Wir verbinden die experimentellen Untersuchungen mit computationaler Modellierung der Hirnaktivitätsdaten um die Netzwerkprozesse im Gehirn besser zu verstehen.

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Upgrade 7 Tesla MRT
Duration: 01.01.2022 bis 31.10.2022

Das Upgrade ermöglicht den vorhandenen 7 Tesla Magnetresonanztomographen der OVGU, auf den aktuellen Stand der Technik der 7 Tesla Ultrahochfeld-MRT zu bringen. Das Upgrade erlaubt die sichere Nutzung von Mehrkanal-Anregungsverfahren (pTx), die zu verbesserter Bildqualität in Regionen des Gehirns führt, die mit bisheriger Technik nicht homogen angeregt werden können (vor allem im Kleinhirn und im unteren Bereich des Temporallappens). Hierzu ist neben dem Hard- und Software-Upgrade des MRT Gerätes, zudem eine neue Mehrkanal-Sendespule notwendig. Das Hardware-Upgrade ist Voraussetzung für die Verwendung der neuesten Software Generation (VE12) und damit der Nutzung von Neuentwicklungen von MRT Mess-Sequenzen, insbesondere der Multiband-Technik. Hier erlauben neuartige Verfahren der Aufnahme eine größeren Anzahl Schichten bei gleicher Messzeit, die auf die im Upgrade enthaltenen leistungsstärkeren Rechner und Steuerungselektronik angewiesen sind. Durch die Maßnahme wird die OVGU somit in die Lage versetzt, auch für die nächsten Jahre voll kompetitive Drittmittelforschung im Rahmen von EU, BMBF und DFG Projekten, wie dem aktuellen SFB 1436 durchführen zu können. Auch für die Exzellenzinitiative der OVGU bildet die Bildgebungsinfrastruktur eine wichtige Säule.

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Vessel distance mapping: Quantification of subcortical arterial and venous vascular patterns to study their interdependency
Duration: 01.07.2020 bis 30.06.2022

Die Integrität und Funktion des Gehirns ist auf den Zu- und den Abfluss von Blut durch das arterielle bzw. venöse Gefäßsystem angewiesen. Subkortikale Strukturen, die an motorischen, sensorischen, kognitiven und verhaltensbezogenen Aufgaben beteiligt sind, werden von den großen Hirnarterien durchströmt. Die Perfusionsterritorien dieser großen Arterien sind zwischen Probanden räumlich variabel. Diese Variabilität beeinflusst die Organisation der kleinen, perforierenden Arterien. Wir vermuten, dass sich diese Variabilität der subkortikalen Perfusionsterritorien von der arteriellen Seite ausgehend durch das Kapillarbett in die Organisation der subkortikalen Venen propagiert. Daher nehmen wir an, dass subkortikale arterielle und venöse Gefäße voneinander abhängig sind und dass unterschiedliche Gefäßmuster existieren. Wenn sich also die Trajektorie eines einzelnen, subkortikalen Gefäßes verändert, könnte dies zu Veränderungen im umgebenden arteriellen und venösen Netzwerk führen, um ein bestimmtes Muster lokaler Gefäßabstände aufrechtzuerhalten. Diese vermutete, wechselseitige Abhängigkeit der arteriell-venösen Muster ist nach unserem besten Wissen bisher nicht umfassend untersucht worden. Um diese Hypothese am lebenden Menschen nicht invasiv zu bestätigen, wurden folgende Ziele identifiziert:(1) Verwendung von Ultra-Hochfeld-MRT und prospektiver Bewegungskorrektur, um die erforderlichen hohen Auflösungen (Voxelgröße < 0,4 mm) zur Darstellung der perforierenden Arterien und Venen zu erreichen(2) Segmentierung des Gefäßsystems mit Hilfe eines Vesselness-Filters und Verwendung einer Entfernungstransformation, um Gefäßdistanzkarten zu berechnen.(3) Finden von gemeinsamen, subkortikalen arteriell-venösen Mustern durch unüberwachtes Clustering.(4) Validierung jedes Verarbeitungsschrittes durch ExpertenDurch Erreichen dieser Ziele wird eine neuartige, vollautomatische Technik zur Analyse von Gefäßdistanzmustern etabliert. Darüber hinaus könnte der Nachweis der Interdependenz des arteriellen und venösen Gefäßsystems einen Einfluss auf die Bildgebung, Diagnose und Behandlung kleiner Gefäße im Allgemeinen haben, da eine gemeinsame Analyse vorteilhafter wäre als die Fokussierung auf eine einzelne Seite des Gefäßsystems. Da die vaskuläre Komponente neurodegenerativer Erkrankungen und des Alterns spezifische Gefäßmusterverläufe induzieren könnte, könnte der vorgeschlagene Ansatz als neuer Biomarker in zukünftigen, longitudinalen Studien eingesetzt werden.

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ABINEP-M4-project 1: Weiterentwicklung von Hochfeld-MR zum in-vivo Mikroskop und Kombination mit MR-PET (Anwendung: Hippocampus-Mapping, Verlaufsdiagnose von Demenzen)
Duration: 01.10.2017 bis 30.05.2022

In this ABINEP sup-project high field MRI and MR-PET will be further developed to detect and visualize hippocampal structure and sub-structures. These methods will be applied in clinical studies with subjects  in prodromal (non-symptomatic) stages and early stages of dementia.

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MEMoRIAL-Module I: Medical Engineering
Duration: 01.09.2016 bis 30.04.2022

Medical imaging encompasses a versatile toolkit of methods to generate anatomical images of a single organ or even the entire patient for diagnostic and therapeutic purposes. Radiation-based imaging technologies are of inestimable importance and hence performed in daily clinical practice.
Electromagnetic radiation may, however, cause undesirable side effects. Consequently, methods allowing for dose reduction are expected to prospectively come into focus. This may specifically hold for patients, who need to be scanned periodically for therapy and/or health progress monitoring.
Instead of performing an entire scan per session, prior knowledge derived from preexisting multimodal image data sourcing, anatomical atlases, as well as mathematical models may be integrated - the latter reducing radiation dose and scan duration thus finally saving health expenditures.
In order to do so, available images and data need to be updated based on newly acquired subsampled data.
The application of prior knowledge may furthermore advance minimally invasive interventions by means of intraoperative image acquisition. Within this context, consecutive scans usually show a high degree of similarity while differing only in probe position and respiratory organ motion. Lower radiation loads vs. significant increases in image frame rate may result when spotting those similiarities based on formerly acquired image information.
The integration of prior knowledge therefore holds a great potential for improving contemporary interventional procedures - especially in the field of interventional magnetic resonance imaging (IMRI).
Graduates in medical imaging science, medical engineering or engineering, computer, and natural science will have the opportunity to work with high-tech diagnostic devices such as x-ray examination and computed tomography (CT), state-of-the-art single-photon emission computed tomography (SPECT) and positron emission tomography (PET) within a structured 4-year/48-month PhD track.

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MEMoRIAL-M1.4 | Use of prior knowledge for interventional MRI
Duration: 01.01.2018 bis 31.03.2022

This sub-project aims at the reconstruction of dynamic time series from fast acquisitions.

Typically, these fast acquisitions are of lower quality (e.g. wrt resolution, contrast, or artefacts) compared to slower scans with higher resolution, the latter being acquired for the purpose of planning. At the same time we know that the object is mainly left unchanged apart from potential non-linear deformations and the presence of an interventional tool (e.g. a needle) with its position being precisely known.

Consequently, a lot is known about the object expecting this prior knowledge to enable the reconstruction of dynamic high resolution and high contrast images.
Therefore, different approaches may be applied including image-based matching and deformation, model-based reconstruction using prior knowledge to support regularisation, or even machine learning methods.

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German Ultrahigh Field Imaging (GUFI II)
Duration: 01.07.2017 bis 31.12.2021

The GUFI network was founded at the end of 2013 as DFG-funded Core Facility. The initial project duration was three years. The overall goal of GUFI is to facilitate and harmonize the access to German Ultra High Field (UHF) sites. GUFI has made important contributions to addressing these challenges and has identified several new areas of common interest to all German UHF sites. A number of unprecedented milestones have been achieved in building a national UHF Magnetic Resonance (MR) community including establishment of a common presentation and access portal for all UHF MR sites; initiation of regular QA; consensus on access procedures, implant handling and RF coil testing; and regular structured communication between all UHF sites. In a second funding phase, starting 2017, the following goals will be pursued:

  • Establishment of an online platform for MR safety training including examination questions to verify attainment of training goals.
  • Continuation and extension of establishment of procedures for safe examinations of subjects with implants. Continuation and refinement of QA activities.
  • Formulation and publication of White Papers.
  • Annual workshops with participation from all GUFI sites to foster communication.
  • Planning of first multicenter UHF trials.
  • Maintenance and extension of the online web-based communications platform.
  • Coordination activities with other international initiatives such as UK7T and Euro-Bioimaging.
  • Preparation of access procedures for the infrastructure to be established at National Biomedical Imaging Facilities in Jülich and Heidelberg that have been applied for as part of the National Roadmap for Research Infrastructures of the German Federal Ministry of Education and Research (BMBF).

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R&D RF-System for Neonatal MR-Imaging
Duration: 16.04.2018 bis 31.12.2021

MR imaging is currently optimized for the examination of adult patients. The examination of newborn and small babies is a challenge for radiology and neonatology (technically and logistically). The startup company Neoscan Solutions is developing a dedicated MR-system for neonatal diagnosis. This system can be installed within a neonatology department due its small footprint (size and weight) and cryogen-free operation. Together with this company and within this cooperation project, we develop the radio-frequency transmit and receive system for this MR operating at the clinically established 1.5T magnetic field strength. This includes transmit and receive RF-coils for the examination of small children but also their implementation into incubators. In addition, patient positioning and patient support will be developed.

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MEMoRIAL-M1.7 | Model-based reconstruction MRI
Duration: 01.10.2017 bis 31.12.2021

The acquisition of MR images might run considerably slow due to the one-dimensional character of the signal and the need to consecutively measure many data points for a single image. Classically, an image cannot be uniquely reconstructed if the number of measured data points deceeds the number of points in the image.

In this project, prior knowledge derived from other sources than the MR acquisition itself will be used to uniquely reconstruct MR images from less-than-complete measurement data, particularly aiming at faster acquisition in moving organs. Therefore, (prior) knowledge such as information on the position of interventional instruments or the subject's breathing motion (deforming abdominal organs whereas not entirely changing the object itself) will be exploited and incorporated into mathematical models - the latter describing these objects and in turn being parameterised based on measurement data.

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R&D Gradient System for Neonatal MR-Imaging
Duration: 15.12.2018 bis 15.11.2021

MR imaging is currently optimized for the examination of adult patients. The examination of newborn and small babies is a challenge for radiology and neonatology (technically and logistically). The startup company Neoscan Solutions is developing a dedicated MR-system for neonatal diagnosis. This system can be installed within a neonatology department due its small footprint (size and weight) and cryogen-free operation. Together with this company and within this cooperation project, we develop the gradient system for this MR operating at the clinically established 1.5T magnetic field strength. This includes control, supervision and optimization of the gradient sub-system.

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ABINEP-M2-project 3: Modellierung Dopamin-induzierter neuronaler Netzwerk-Aktivität / "Learning conditional associations: rich temporal context and involvement of hippocampus / medial temporal lobe"
Duration: 01.05.2017 bis 31.10.2021

Animals exploring unknown environments face problems at multiple time-scales: in the short run, they must solve problems of pattern recognition, scene understanding, decision making and action selection while, in the long run, they must also develop strategies for building an internal representation of the environment as a basis for causal understanding / generative modelling.  From a computational point of view, the main difficulty is representing and learning the rich temporal structures and conditionalities that encapsulate the co-dependencies between environment and actions.
Current behavioural tasks – e.g., sequence learning, sequential reaction time tasks, conditional associative learning – barely touch upon these difficult issues.  To address this more directly, we will study human learning of arbitrary sensorimotor mappings in the presence of rich temporal context, as well as the neural correlates of such learning in networks involving the hippocampus / medial temporal lobe.  Specifically, we hypothesize that rich, quasi-naturalistic, temporal context will (i) dramatically facilitate learning by means of (ii) engaging hippocampus and medial temporal lobe structures.
To investigate these two hypotheses, we will monitor human learning of visuomotor associations in temporal contexts of different complexity.  To this end, we will develop novel, quasi-naturalistic, temporal sequences with statistical structure over several time-scales.  To investigate neural correlates, we will study functional correlations of voxel-based BOLD activity in pairs of (small) brain areas – e.g., hippocampus and inferior temporal cortex – relying on 3T or 7T high-resolution MRI.  Recent work, by ourselves and others, shows that voxel-level functional correlations can delineate with high fidelity the cortical circuits engaged in different task states.

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MEMoRIAL-M1.2 | Under-sampled MRI for percutaneous intervention
Duration: 01.05.2017 bis 31.07.2021

Background
Undersampling MR images leads to an insufficient amount of data for conventional reconstruction techniques, making it an ill posed inverse problem. Deep neural networks provide promising solutions to the problem, but lack explainability.

Objective
MRI acceleration, especially golden angle radial sampling, in the process making real time MRI possible.

Methods
>> Utilizing and improving data-driven neural network approaches and their analysis

Results
>> Up-to-date deep learning reconstruction methods for undersampled radial MR signal data in image and signal domain with competitive results in that field of research

Conclusions
Current methods still mark the starting point since they are still missing key points like holoporphic activation functions for computing complex gradients throughout neural nets.

Orignality
>> Problem specific methods that are tailored to the underlying complex valued MR problem

Keywords
>> MRI, undersampling, reconstruction, deep learning, unblackboxing

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Gefäßdistanzkartierung: Quantifizierung der subkortikal arteriellen und venösen Gefäßmuster um deren Wechselwirkung zu untersuchen
Duration: 01.07.2020 bis 30.06.2021

The integrity and function of the brain rely on the supply and draining of blood through the arterial and venous vasculature, respectively. Subcortical structures, involved in motor, sensory, cognitive and behavioral tasks, are perfused by the major cerebral arteries. The perfusion territories of these large arteries are spatially variable between subjects. This variability influences the organization of small, perforating arteries. We hypothesize that this variability in subcortical perfusion territories is propagated from the arterial side through the capillary bed into the organization of subcortical veins. Thus, we suspect that subcortical arterial and venous vasculatures are interdependent and that distinct vessel patterns exist. Therefore, if the trajectory of an individual, subcortical vessel is altered, this could induce changes within its surrounding arterial and venous network to maintain a specific pattern of local vessel-vessel-distances. To our best knowledge, this hypothesized interdependency of the arterial-venous patterns has not been studied comprehensively to date. To validate non-invasively this hypothesis in living humans, the following objectives have been identified:

  1. Use ultra-high field MRI and prospective motion correction to achieve the required high resolutions (voxel size < 0.4mm) to depict the perforating arteries and veins
  2. Segment the vasculature using a vesselness filter and apply distance transform to compute vascular distance maps
  3. Find common, subcortical arterial-venous patterns using unsupervised clustering
  4. Validate each processing step thoroughly by experts


By addressing these objectives, a novel, fully automatic technique to analyze vascular distance patterns will be established. Further, proving the interdependency of the arterial and venous vasculature could have an impact on small vessel imaging, diagnose, and treatment in general, as an interdependency might render a joint assessment more promising that focusing on a single side of the vasculature. As the vascular component of neurodegenerative diseases and aging could induce specific vessel-vessel-pattern progressions, the proposed approach could be used as a new biomarker in future, longitudinal studies.

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Human imaging at meso-scale
Duration: 01.07.2020 bis 31.12.2020

It is known from animal work that most mechanisms limiting neural resources manifest at the level of brain microstructure and influence brain functions at different hierarchical levels, such as brain macrostructure, neuronal networks, and behavioural phenotypes. Current research on neural resources in humans, however, often lacks a mechanistic level of explanation due to missing technology and/or methodological expertise needed to describe neuronal changes at the meso-scale (i.e. at the level of cortical layers or neuronal ensembles). This hinders knowledge transfer from mechanistic insights at the micro-scale gained in animal research to macro-scale human brain models and interventions. The CRC initiative has the overall goal to systematically investigate neural resources at the micro-, meso-, and macro-scale by taking an interdisciplinary and multi-scale approach and to link changes in the functional and structural architecture of cortical and subcortical micro-circuits to behavioural performance and cognitive interventions. Technological advancements in meso-scale brain imaging, meso-scale data modelling, and multi-modal and multi-scale data interaction can bridge this gap. The aim of Z02 is to develop and test novel technologies using ultra-high resolution 7 Tesla magnetic resonance imaging (7T MRI) for wider applications in human subjects and primates and to provide them to the researchers of the CRC projects by ensuring (i) usage of appropriate and state-of-the-art MR-sequences that offer reproducible and optimised data quality and (ii) computational tools and analysis pipelines for multi-modal and multi-scale data modelling within and across individuals. Z02 has the overarching goal of modelling the human cortex in three dimensions, that is, both in plane at the cortical surface (dimensions 1&2) and in cortical depth (dimension 3, cf. Kuehn & Sereno 2018, Fig. 1). This approach extends the frequently applied localisation of function in cortical regions, e.g. Brodmann areas, or more advanced and ambitious columnar mapping, to a novel level of detail relevant for cognitive processes (e.g., Larkum et al. 2018). This will allow the CRC projects to target research questions on neural resources in a novel yet undiscovered dimension, while at the same time enabling Magdeburg to maintain its leading position for human brain imaging in Europe.

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CRC 779, Project A07 "Functional control of dopamine release in humans: changes in aging and the modifying role of the locus coeruleus (LC)"
Duration: 01.01.2016 bis 31.12.2019

The goal of project A07 is to delineate the functional network level regulation of dopamine release in response to novelty and action for reward and to investigate the relationship between dopamine release and memory consolidation in young and old adults. To achieve these goals, we will continue our successfully established multimodal approach of combining imaging at 3T, 7T and PET. We will achieve a direct integration of fMRI and dopamine release by using a new, truly simultaneous MR-PET facility in Magdeburg. We will also determine whether a norardrenergic brain region, the locus coeruleus, may be a bottleneck for dopamine-release in the hippocampus.

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CRC 779, Project A12 "Habenular (dys)function in decisions on approach and avoidance" (Prof. Speck/Prof. Ullsperger)
Duration: 01.01.2016 bis 31.12.2019

Project A12 addresses the role of the habenula (Hb) in motivated behaviour of humans. The Hb is an important relay on a major descending pathway from the forebrain to the brain stem with predominantly inhibitory influence on monoaminergic nuclei, thereby controlling release of dopamine and serotonin to the forebrain. The project aims at understanding the contribution of the Hb to active and passive avoidance and to learning from aversive events. This comprises studying habenular activity, its structural and functional embedding in pallido-habenulo-mesencephalo-striatal networks, and its neurochemical interactions. To this end, high-resolution structural, diffusion-weighted and functional MRI, pharmacological challenges, and in-vivo receptor density mapping using positron emission tomography will be performed in healthy volunteers. Understanding habenular functions is important not only for fundamental neurosciences but also for clinical neuropsychiatry, because dysfunction of the Hb has been suggested to contribute to the pathophysiology of psychiatric disorders, such as affective disorders and addiction. Therefore, we will search for volume and connectivity aberrations of the Hb in patients with addiction.

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STIMULATE
Duration: 01.01.2015 bis 31.12.2019

Die Forschungsgruppe Interventionelle MR-Bildgebung innerhalb des Forschungscampus STIMULATE erforscht gemeinsam zwischen SIEMENS und der OVGU spezielle Protokolle (Sequenzen) für den Einsatz der MRT-Bildgebung in der Intervention, und testet diese auf ihr Verbesserungspotenzial. Die primären Ziele sind Echtzeitfähigkeit der Bildgebung bei hohem Tumorkontrast und gemeinsam mit dem weiteren Partner Metria Inc. eine automatische Verfolgung des OP-Instruments zur permanenten Visualisierung. Mittelfristig sollen neue Kontrastmechanismen wie Gewebeelastizität oder Leitfähigkeit komplementäre Informationen zur Tumoridentifikation und -visualisierung liefern.

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RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy
Duration: 01.08.2014 bis 31.07.2019

In this project, funded by the National Institute of Health, methods for prospective motion corrected MRI are developed. These methods enable examination of motion-prone subjects without the need for rescanning and with improved image quality.

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Highly Accelerated Distortion-Free Diffusion-Weighted MR Imaging at Ultra High Field (7T): Gray Matter Characterization (DFG)
Duration: 01.05.2016 bis 31.05.2019

Single-shot echo-planar imaging (EPI) is a well-established technique with moderate spatial resolution but high imaging efficiency. It is widely adapted in various brain imaging applications such as functional MRI (fMRI), perfusion weighted MRI, and diffusion tensor imaging (DTI). EPI, however, is very sensitive to inhomogeneities induced by the main magnetic field as well as magnetic susceptibility differences in the object. These effects cause phase disturbances due to the low effective bandwidth in the phase encoding direction, leading to distortions of the image geometry and signal intensity. Moreover, in EPI-based diffusion weighted imaging (DWI), these distortions additionally vary according to the diffusion encoding direction due to eddy currents induced by the rapid and large changes of the magnetic field associated with the ramp-up and ramp-down of these encoding gradients. Since field inhomogeneities are directly proportional to the strength of the main magnetic field, these distortions are increased at high field strengths of 3 Tesla and above, and become a significant obstacle for EPI-based applications at ultra high field (UHF) such as 7T. In this project, we propose the development, implementation and testing of an improved approach to measure, characterise, and compensate strong EPI distortions. The development and evaluation will be performed at 7T in phantoms and human subjects. The project covers an implementation of the improved method for fMRI applications and its further extension for reliable DTI applications. Significantly improved stability and imaging properties of EPI allowing more sensitive experimental results and higher positional accuracy are predicted for the proposed method. This will be achieved without prolonged scan times since all data directly enter the DTI results.

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Motion Correction for MRI, Kooperation mit KinetiCor
Duration: 01.11.2013 bis 31.10.2017

Innerhalb des Unterauftrages #1 zwischen KinetiCor und der OVGU werden Methoden, welche in meiner Abteilung (BMMR) an der OVGU entwickelt wurden, an einen neuen Standort transferiert und erweitert. Die Methoden wurden auf einem 7T MRT des Baujahres 2004 entwickelt und werden für Geräte neuester Bauart und unterschiedlicher Magnetfeldstärke weiterentwickelt. Dies bedingt Modifikationen und Anpassungen der Methoden inklusive neuer Entwicklungen zur Ankopplung und Kalibrierung der Geräte sowie Messmethoden. Die Bewegungskorrektur ist ein wesentlicher Aspekt unseres aktuellen Forschungsportfolios und daher sind diese gemeinsamen Forschungsarbeiten mit dem Partner KinetiCor sowie der Universität Freiburg, welche ebenfalls bilateraler Partner von KinetiCor ist, von wesentlichem Interesse für unsere Forschung, welche hiervon ebenfalls profitiert. Ich ordne die Arbeiten daher als Anwendungsforschung mit dem Ziel des Erkenntnisgewinns sowie Erweiterung der möglichen Anwendungen auf weitere Feldstärken und Gerätekonfigurationen ein.

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German Ultrahigh Field Imaging (GUFI)
Duration: 01.12.2013 bis 31.05.2017

Within the past few years, seven centers for human ultra-high-field (UHF) magnetic resonance (MR) imaging have been set up in Germany. To make this expensive and highly complex technology accessible to a larger number of researchers, organizational cooperation of the UHF MR centers is crucial. To achieve this goal, all German UHF centers have decided to establish a national network called German Ultrahigh Field Imaging (GUFI), which will be coordinated by the centers in Essen and Magdeburg. Within the proposed project, vital organizational structures will be created at both the administrative and technical levels. In particular, communication between the centers and external users will be facilitated via a web portal. On the technical level, the project involves the exchange of latest imaging protocols and in particular the development of new approaches to ensure common qualitystandards for the obtained image and spectral data, optimized for the challenges of UHF MR systems, so that external users can be assured of ideal conditions and so that measurements on different UHF MR systems can be compared.

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Does multivariate pattern analysis of functional magnetic resonance data benefit from high resolution and
Duration: 01.07.2013 bis 31.12.2016

Multivariate pattern analysis (MVPA) of functional magnetic resonance data has recently been widely used inthe neurosciences. MVPA promises to yield information about brain function with high spatial resolution.Recently, however, conflicting results were published concerning the information carried by functionalmagnetic resonance data at different spatial scales and their contribution to classification analyses. In thepresent project, we intend to investigate to what degree the high spatial resolution and sensitivity yielded athigh magnetic field strength contributes to an improved classification of functional activation patterns. To thisend we vary field strength (3T and 7T), spatial resolution and sensitivity and investigate their influence understimulation conditions that create neuronal excitation patterns in the sub-millimeter versus multiple-millimeterscale. The overall goal of the project is the characterization of factors influencing multivariate pattern analysisof functional magnetic resonance data and, subsequently, the optimization of future experimental designsusing MVPA.

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HiMR - Ultra-High Field Magnetic Resonance Imaging
Duration: 01.11.2012 bis 31.10.2016

The High field Magnetic Resonance (HiMR) Initial Training Network aims to train the future leaders of academic and industrial research in the fundamental science and novel applications of ultra-high field (UHF) in vivo magnetic resonance (MR), in order to address an increasing and currently unmet demand from academia and industry for such specialists. The highly complex and multi-faceted nature of UHF MR means that excellent training can only be provided by immersing ESRs in an environment that integrates different research areas, sectors and groups.

The HiMR ITN is centred on a cutting edge, multidisciplinary research program that exploits the complementarities of the participants. This research programme is organised into four themes each focused on a crucial area of development of UHF. The first focuses on improved structural imaging, advancing our understanding of the origins of contrast in MRI scans and developing non-invasive biomarkers for multiple sclerosis. The second theme is centred upon exploiting UHF to develop ultra-high resolution functional MRI (fMRI) which will be very important in basic neuroscience research. It also aims to make fMRI more quantitative, thus encouraging its uptake in the clinic. The third theme aims to exploit the enhanced sensitivity of MR spectroscopy (MRS) at UHF in developing highly specific biomarkers. The final theme will develop novel hardware for both research and in the clinic, and methods of monitoring and correcting motion which limits in-vivo MR resolution. Finally the HiMR ITN will provide a unique opportunity to measure safety outcomes over a large group of workers.

The interdisciplinary and intersectoral training program will provide a platform for training ESRs to become specialists in UHF MR, whilst also furnishing them with experience of a broad range of work environments, experimental techniques and theoretical knowledge relevant to the full range of in vivo MR.

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Highly Accelerated Distortion-Free Diffusion-Weighted MR Imaging at Ultra High Field (7T) (DFG)
Duration: 01.09.2012 bis 31.08.2015

Single-shot echo-planar imaging (EPI) is a well-established technique with moderate spatial resolution but high imaging efficiency. It is widely adapted in various brain imaging applications such as functional MRI (fMRI), perfusion weighted MRI, and diffusion tensor imaging (DTI). EPI, however, is very sensitive to inhomogeneities induced by the main magnetic field as well as magnetic susceptibility differences in the object. These effects cause phase disturbances due to the low effective bandwidth in the phase encoding direction, leading to distortions of the image geometry and signal intensity. Moreover, in EPI-based diffusion weighted imaging (DWI), these distortions additionally vary according to the diffusion encoding direction due to eddy currents induced by the rapid and large changes of the magnetic field associated with the ramp-up and ramp-down of these encoding gradients. Since field inhomogeneities are directly proportional to the strength of the main magnetic field, these distortions are increased at high field strengths of 3 Tesla and above, and become a significant obstacle for EPI-based applications at ultra high field (UHF) such as 7T. In this project, we propose the development, implementation and testing of an improved approach to measure, characterise, and compensate strong EPI distortions. The development and evaluation will be performed at 7T in phantoms and human subjects. The project covers an implementation of the improved method for fMRI applications and its further extension for reliable DTI applications. Significantly improved stability and imaging properties of EPI allowing more sensitive experimental results and higher positional accuracy are predicted for the proposed method. This will be achieved without prolonged scan times since all data directly enter the DTI results.

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Neuron-Verbund "REVlS": Restitution von Sehleistungen nach Schlaganfall durch nicht-invasive elektrische Hirnstimulation
Duration: 01.04.2012 bis 31.03.2015

1. Vorhabenziel; REVIS will study visual system plasticity following posterior infarcts in stroke patients and animals. Specifically, we will evaluate the effects of a new non-invasive current brain stimulation method to achieve vision restoration. There are 11 Mio stroke patients worldwide that suffer from damage to lhe visual system, with 2.1 Mio new cases annually which have significant subjective impairments in everyday life. We attempt to improve brain plasticity with non-invasive alternating and direct current stimulation (applied transorbitally or transcranially) and thereby achieve clinical improvements such as better independence, return to work, improved quality of Iife (orienting, reading) and greater mobility.  2. Arbeitsplanung; We will look for signs of local and global plasticity (changes in receptive fields, activations and connectivities) in strokepatients with visual field loss before and after brain current stimulation to achieve vision restoration using functional tests, EEG, and MRI measurements.The Magdeburg part of the project will be carried out by B. Sabel, C.Gall (Inst. of Med. Psychol., project coordination) and O. Speck (Inst. of Exp. Physics), all at the University of Magdeburg. As part of the REVIS consortium, human studies will also be conducted as a joint effort with lhe partners P. Rossini (Rome) and T. Tatlisumak (Helsinki) and animal studies with V. Waleszczyk (Warsaw). Commercial collaborating partner is EBS Technologies GmbH (Kleinmachnow).

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4D Phasenkontrast Magnetresonanzbildgebung bei 3Tesla für den Ingenieursbereich, Kooperation mit Volkswagen
Duration: 15.08.2014 bis 31.12.2014

Die Phasenkontrast MR Bildgebung ist im klinischen Einsatz ein viel genutzte Technik zur Darstellung von Flussverhältnissen in Gefäßen, z.B. im Aortenbogen oder in den intrakranialen Gefäßen. Im vorliegenden Projekt wird diese Technik gemeinsam mit dem Industriepartner Volkswagen im nicht-medizinischen Umfeld angewendet um ingenieurwissenschaftliche Fragestellungen zu beantworten.

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Forschungscampus STIMULATE, Interventionelle MRT
Duration: 01.03.2014 bis 31.12.2014

Für jede Intervention ist die genaue Kenntnis der Position der Instrumente relativ zur Patientenanatomie entscheidend. Zudem ist die räumliche Übereinstimmung der Voraufnahmen für die Planung des Eingriffs mit der aktuellen intraoperativen Bildgebung essentiell. Daher stehen unterschiedliche Methoden der Positionserfassung von Instrumenten im Patienten, von Patienten in Bildgebungsgeräten und physiologisch bedingter Patientenbewegung im Forschungsfokus. Auf Basis der Erkenntnisse über die unterschiedlichen Trackingmodalitäten, werden die Bildgebungsmodalitäten und die Instrumente hinsichtlich Ihrer Eignung zur Kombination mit diesen Geräten evaluiert. Über die direkte und automatische Positionierung der Bildgebung und Instrumente hinaus, können derartige externe Trackingsystem während des Eingriffs und der Bildgebung für die Erfassung physiologischer Parameter genutzt werden.

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Euro-BioImaging - Research infrastructure for imagingtechnologies in biological and biomedical sciences (Preparatory Phase)
Duration: 01.12.2010 bis 31.05.2014

MI - Access to Innovative TechnologiesThe objectives of WG Access to Innovative Technologies - Medical Imaging (MI) are

  • To survey existing European infrastructure enabling innovative MI technologies.
  • To identify the needs of the scientific community with regard to instrument developments and access to the identified innovative MI technologies including Ultra-High Field MR (UHF-MR), Novel X-ray based Phase-Contrast Imaging (PCI) and Emerging Imaging Technologies (EIT) such as combination of MR and PET, SPECT, or MEG (MR-PET, MR-SPECT, MEGMR), Electron Paramagnetic Resonance Imaging (EPRI), and Magnetic Particle Imaging (MPI).
  • To search for additional emerging MI developments, which may be considered for inclusion in the forward planning of Euro-BioImaging infrastructure.
  • To determine the bottlenecks for providing access to innovative MI technologies.
  • To explore the feasibility of providing access to the identified innovative MI technologies by proof-of-concept studies.
  • To develop a comprehensive, long-term plan for the implementation of European access to innovative MI technologies.

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STIMULATE -> Bildgebung
Duration: 01.03.2013 bis 28.02.2014

In der Planung, Durchführung und Kontrolle minimal-invasiver Eingriffe werden unterschiedliche Bildgebungsmodalitäten wiederholt genutzt. Die Überlagerung der Bilddaten ist jedoch oft nur eingeschränkt oder durch nachträgliche Registrierung möglich.

In STIMULATE werden im Projekt "Bildgebung" Möglichkeiten zur weiteren Verbesserung der Modalitäten für den Einsatz zur Planung und Durchführung von bildgestützten minimal-invasiven Eingriffen in Machbarkeitsstudien evaluiert. Hierbei werden innovative Ansätze für die Darstellung mittels 3D-roboterbasierter Angiographie und der Kernspintomographie, neuartige Photonendetektoren und intravaskuläre Bildgebung untersucht, um langfristige Forschungsprogramme in der Hauptphase zu definieren. Im Fokus stehen z.B. Möglichkeiten zur Verbesserung der Bildqualität, zur Verkürzung der Messzeit und Reduktion der Patientendosis sowie zur Erhöhung der Sicherheit des Arbeitsbereiches und der Nutzerfreundlichkeit.

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Untersuchung glutamaterger Störungen bei depressiven Patienten anhand STEAM MRS im Hochmagnetfeld
Duration: 01.06.2010 bis 31.03.2013

Advances in Magnetic Resonance (MR) neuroimaging tools have greatly contributed to recent developments in the understanding of biological processes in psychiatric diseases such as Major Depressive Disorder. Using functional MRI (fMRI), a subset of specific brain regions that experience characteristic alterations of brain responses during well-delineated psychological conditions have been identified. While some consistencies were found with structural MR assessments and postmortem studies, the molecular basis of these alterations is largely unknown. This is due, primarily, to the inherent technical difficulties encountered in the leading non-invasive imaging technique available: Magnetic Resonance Spectroscopy (MRS). In animal models, and postmortem studies in humans, deficiencies in specific cellular targets within the glutamatergic system, e.g. the glial glutamate re-uptake from the synaptic cleft and its subsequent conversion to glutamine, have been reported. Such glutamatergic origins of dysfunction are further supported by pharmacological evidence of the beneficial effects of glutamate-modulating agents in depression, suggesting treatment-related changes of metabolite levels in a subset of regions. Further systematic investigations in psychiatric neuroimaging studies are primarily hindered by technical limitations resulting in an inability to discern glutamate and glutamine in MR-spectra at field strengths of up to 3 Tesla. Recent single-voxel solutions to circumvent the lack of sufficient line separation resulted in relatively large voxels that had to be measured for up to 20 minutes to obtain reliable metabolite separation. Studies to date were thus unable to systematically investigate brain regions with adequate resolution given the functional heterogeneity of key brain regions known from functional imaging studies. The long acquisition duration for each location further prevented investigations of regional specificity via assessments of a greater numbers of regions. Our project thus aims to develop an optimized MRS method to accomplish these goals using a STEAM-based sequence at ultra high field strength of 7 Tesla.

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INUMAC - Imaging of Neuro Disease Using High Field MR and Contrastophors
Duration: 01.01.2008 bis 31.12.2012

The major goals of this project are to develop new technology to overcome the limitations of ultra high field imaging in humans (higher than 7 Tesla). The project consortium consists of University Freiburg, Siemens Medical Systems, and Bruker Biospin. The University Magdeburg is sub-contractor to the University Freiburg and Siemens Medical Systems and involved in the development of methods for real-time scanner control and parallel transmission.

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Linking the Microscopic and Macroscopic World: Systematic Study of Water Macromolecule Exchange as a Basis for Ultra-High Field MR Phase Contrast Imaging, CBBS
Duration: 01.10.2008 bis 31.12.2012

The project aims at linking microscopic water-macromolecule exchange processes with the macroscopic MRI phase contrast detected at 7-T in the human brain. As the basis for further development, we will first characterize the WME interaction under carefully controlled experimental conditions with high resolution NMR spectroscopy.Different macromolecule parameters, such as molecular size, molecular weight, temperature, viscosity, pH, ionic strength etc. will be studied systematically. This will be extended to structural factors (protein sub-domains, ?-helix and ?-sheet content, etc), that are closely related to protein conformation. Protein cleavage and 2D/3D NMR spectroscopy will be used to study the correlation between structural factors and WME.To extend the WME model for in vivo quantification, a good understanding of the macromolecule distributions in brain tissues and their contributions to the phase contrast is required. This will be achieved by systematic macromolecule determination in tissue extracts from different mouse brain regions (cortex, cerebellum, striatum, hippocampus, thalamus, etc) and different cell components, including cytosolic, myelin, cell membrane, and synaptic fractions. The macromolecule distribution will be correlated with in vivo phase imaging and magnetization transfer studies of the same mouse to quantitatively determine the macromolecule contribution to the phase contrast. This will be further extended with an EAE (experimental autoimmune encephalomyelitis) mouse model to study multiple sclerosis. A detailed understanding of the WME and the in vivo phase contrast from animal studies will form the basis for quantitative phase imaging studies in MS patients.The project addresses the following main scientific questions: i. How do macromolecules interact with water? ii. Is it possible to observe dynamic protein conformation changes using WME? iii. What is the in vivo macromolecule distribution and its contribution to the WME frequency shift as determined by MR phase contrast imaging? iv. How can the WME model be used to study quantitatively in vivo pathologies involving macromolecule alternation? This project is based on a four-partner-network between the Department of Biomedical Magnetic Resonance, the Institute for Chemistry, the Dept. Neurology II, Otto-von-Guericke University, and the Institute for Neurobiology (LIN).

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Entwicklung von Hochfrequenzspulen für 7T Magnetresonanztomographie
Duration: 01.10.2008 bis 31.03.2012

Die Bildqualität in der Magnetresonanztomographie wird u.a. durch die Stärke und Homogenität des messbaren NMR-Signals bestimmt. Mit der Einführung des 7T MRT hat hier eine neue Ära begonnen, mit Magdeburg als Vorreiter. Das Potential dieses Ultrahochfeldgerätes (UHF) kann derzeit noch nicht voll ausgeschöpft werden, da die Hochfrequenz-Sende- und -Empfangstechnik optimiert werden muss. Hierzu werden spezielle Spulenkonfigurationen wie etwa Phase-Array-Spulen benötigt, welche derzeit nur für den Kopfbereich und von nur einer Firma kommerziell angeboten werden. Die Etablierung von HF-Kompetenz und die Entwicklung optimaler Spulen ist das Ziel des Antrages. Die erworbenen Kenntnisse und technischen Fähigkeiten sollen sekundär in Kooperationen mit der Wirtschaft und anderen Instituten weiterentwickelt und vermarktet werden. Das Projekt fügt sich harmonisch in den Schwerpunkt Biophysik und weiche Materie der FNW ein und kann als fakultätsübergreifender Kristallisationspunkt für die Initiativen im Bereich Medizintechnik gesehen werden.

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Imaging of Neuro Disease Using High Field MR and Contrastophors (INUMAC)
Duration: 01.01.2009 bis 31.10.2011

The major goals of this project are to develop new technology to overcome the limitations of ultra high field imaging in humans (higher than 7 Tesla). The project consortium consists of University Freiburg, Siemens Medical Systems, and Bruker Biospin. The University Magdeburg is sub-contractor to the University Freiburg and Siemens Medical Systems and involved in the development of methods for real-time scanner control and parallel transmission.

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Neue Methoden für die Ultrahochfeld Magnetresonanztomographie - Preis für Angewandte Forschung
Duration: 01.01.2008 bis 31.12.2010

Preisgeld für den Preis für Angewandte Forschung in Sachsen-Anhalt 2007, zur Förderung von Wissenschaft und Forschung.

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Teilprojekt A3 des SFB 779/1: Perzeptuelles Verstärkungslernen: Der Beitrag neuronaler Fehlersignale zur visuellen Mustererkennung
Duration: 01.01.2008 bis 31.12.2010

Menschliche visuelle Mustererkennung unterliegt einer erheblichen Plastizität: Wenn Probanden über längere Zeit trainieren, einfache Reizmuster zu unterscheiden, dann können sie die Präzision ihrer Antworten erheblich verbessern, solange Trainings- und Testbedingungen sehr ähnlich sind. Die genauen Mechanismen dieser hochselektiven Verbesserung visueller Mustererkennung sind bis heute nicht geklärt.

In diesem Projket wird untersucht, wie der Aufbau perzeptueller Kompetenzen im visuellen System durch sog. Fehlersignale unterstützt wird. Fehlersignale resultieren aus Interaktionen der Basalganglien und des präfrontalen Kortex und indizieren Differenzen zwischen erwarten und tatsächlichen Ereignissen. Diese Differenzen werden als Belohnung / Bestrafung oder, abstrakter, als Erfolg / Misserfolg kodiert und sind Bestandteil des Systems des Verstärkungslernens, das diese Feedback-Inforation verwendet, um Verhalten in Bezug auf das gewählte Ziel zu optimieren. Die hier geplanten Studien haben das Ziel, neutrale Mechanismen von perzeptuellem Lernen durch Fehlersignale zu identifizieren. Dabei kommen neue MR Verfahren (Anwendung von statistischer Mustererkennung auf hochauflösende 3T und 7T fMRT-Daten) und eine Kombination multimodaler räumlich-zeitlicher Parameter zum Einsatz.

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Deutsch-Chinesischer Ultra-Hochfeld MRT Workshop German-Chinese Ultra-High-Field MRI Workshop
Duration: 01.01.2010 bis 30.06.2010

Motivation für die Durchführung díeses Treffens von Wissenschaftlern auch China und Deutschland von Forschungsstätten mit Hochfeld-Magnetresonanztomographie (MRT) ist die Etablierung von Hochfeld (7T) Tier-MRT und die Errichtung des ersten 7T-Human-MRT in China. Zudem befindet sich in Deutschland die größte Forschungsgemeinschaft im Bereich der Hochfeld-MRT außerhalb der USA und in Magdeburg wurde 2005 der erste 7T-Human-MRT in Europa in Betrieb genommen.

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Adaptive distortion correction techniques for high-field magnetic resonance neuroimaging
Duration: 01.11.2007 bis 28.02.2010

The use of single-shot echo-planar imaging (EPI) has grown dramatically over recent years. A number of advanced brain imaging applications in functional neuroimaging, e.g. functional MRI (fMRI) and diffusion tensor imaging (DTI), use EPI as the imaging module. EPI, however, is susceptible to a number of imaging artefacts and geometric image distortions due to inhomogeneities of the main magnetic field within the sample. These inhomogeneities induced by magnetic susceptibility differences in the sample or by main field inhomogeneities are often regarded as inherently constant in time. Especially for long time-series acquisitions with continuous and repetitive scans, system instabilities, ferro-shim heating or subject s motion and respiration can introduce time dependant changes in the field homogeneity. These result in time variant changes in image distortions leading to degradation and to artefacts in time-series analyses. These effects become increasingly important at high field strengths of 3 Tesla and above, and can become a significant obstacle for EPI applications at 7T. In this project we propose an approach to dynamically measure, characterise and compensate for geometric image distortions in EPI. The project covers various EPI applications ranging from functional MRI to diffusion tensor imaging. The methods, which are to be developed, will be evaluated at various field strengths ranging from 1.5T to 7T. They will significantly improve stability and imaging properties of EPI to allow more sensitive experimental results and higher positional accuracy.

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Faster than BOLD: New Concepts and Applications for the Examination of Spatiotemporal Mechanisms of Brain Activity
Duration: 01.09.2004 bis 31.08.2007

Neue Methoden zur Untersuchung der neuronalen Aktivierung mittels Magnetresonanztomographie werden in idesem von der Hertie-Stiftung geförderten Projekt entwickelt und untersucht. Das gängige Messverfahren beruht auf dem BOLD Effekt, welcher relativ langsam (1s) einen indirekten Effekt der Gehirnaktivität misst. Neue Verfahren sollen eine direktere und schnellere Messung erlauben.

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Highly efficient 31P-CSI using SSFP methods
Duration: 01.04.2005 bis 31.08.2007

31P-Spektroskopie ist von höchstem Interesse, da viele entscheidende Metaboliten des Zellstoffwechsels MR-sichtbare Moleküle sind, welche Phosphor enthalten. Pathologische Veränderung des Zellstoffwechsels, wie etwa durch ischämische Ereignisse hervorgerufen, können mittels 31P-Spektroskopie detektiert, beurteilt und in ihrem Verlauf oder während Therapie verfolgt werden. Hierzu gehören unter anderem Pathologien, die durch Gefäßerkrankungen hervorgerufen werden, wie etwa Schlaganfälle des Gehirns, Herzinfarkte oder aufgrund peripherer Gefäßerkrankungen minderdurchblutete Muskelgruppen. Die MR-spektroskopische Messung der 31P-Metaboliten ist jedoch aufgrund ihrer geringen Konzentration und Sensitivität im Vergleich zur Protonenbildgebung sehr zeitaufwendig. Durch die Kombination von hohen statischen Magnetfeldern mit effizienten und schnellen Verfahren zur Signalgenerierung und Bildaufnahme aus der 1H-Bildgebung können spektroskopische 31P-Aufnahmen in für die klinische Anwendung akzeptablen Zeiten durchgeführt werden. Hierzu soll in diesem Projekt das neu entwickelte und vorgestellte Verfahren des 31P-SSFP CSI bis zur klinischen Anwendbarkeit weiterentwickelt und an Patientengruppen mit verschiedenen Pathologien eingesetzt werden. Neben dieser Entwicklung und Erprobung der statischen Bildgebung soll auch untersucht werden, inwieweit die Methode sich zur direkten Visualisierung der lokalen metabolischen Transferrate von Phosphokreatin mittels Magnetization Transfer Imaging einsetzen lässt.

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Patents
  1. Method for magnetic resonance imaging of moving objects (103 28 423.0)
  2. Method for magnetic resonance using steady state signals (10138961.2)

 

Publications

2024

Peer-reviewed journal article

Exploration of interpretability techniques for deep COVID-19 classification using chest X-ray images

Chatterjee, Soumick; Saad, Fatima; Sarasaen, Chompunuch; Ghosh, Suhita; Krug, Valerie; Khatun, Rupali; Mishra, Rahul; Desai, Nirja; Radeva, Petia; Rose, Georg; Stober, Sebastian; Speck, Oliver; Nürnberger, Andreas

In: Journal of imaging - Basel : MDPI, Bd. 10 (2024), Heft 2, Artikel 45, insges. 22 S.

Dissertation

Incorporation of prior knowledge into dynamic MRI reconstruction

Sarasaen, Chompunuch; Rose, Georg; Speck, Oliver

In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektrotechnik und Informationstechnik 2024, 1 Online-Ressource (xix, 129 Seiten, 28,98 MB) [Literaturverzeichnis: Seite 101-122][Literaturverzeichnis: Seite 101-122]

2023

Abstract

The effect of imaging parameters, aging, and circadian rhythm on Freesurfer's estimates: A single subject study at 7T over 7 years

Mattern, Hendrik; Lüsebrink-Rindsland, Jann Falk Silvester; Speck, Oliver

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 2017

Abstract

Concurrent MR‐PET investigation of memory consolidation and dopaminergic modulation in ageing

Yi, Yeo-Jin; Garcia-Garcia, Berta; Johansson, Jarkko; Betts, Matthew; Speck, Oliver; Kreißl, Michael; Düzel, Emrah; Hämmerer, Dorothea

In: Alzheimer's and dementia - Hoboken, NJ : Wiley, Bd. 19 (2023), Heft Suppl. 24, Artikel e082937, insges. 1 S.

Abstract

Wireless MRI metasurface to enhance head coil performance

Kowal, Robert; Vogt, Ivan; Hubmann, Max Joris; Speck, Oliver; Maune, Holger

In: Konferenz: 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Sydney, 24. - 27. Juni 2023, IEEE EMBC 2023 - Sydney

Abstract

Enhancing vessel continuity in deep learning based segmentation using maximum intensity projection as loss

Chatterjee, Soumick; Varma Chintalapati, Karthikesh; Radhakrishna, Chethan; Ram Kumar, Sri Chandana Hudukula; Sutrave, Raviteja; Mattern, Hendrik; Speck, Oliver; Nürnberger, Andreas

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 3769 [Meeting: ISMRM & ISMRT Annual Meeting & Exhibition, Toronto, 03-08 June 2023]

Abstract

Exploiting the inter-rater disagreement to improve probabilistic segmentation

Chatterjee, Soumick; Gaidzik, Franziska; Sciarra, Alessendro; Mattern, Hendrik; Gabor, Janiga; Speck, Oliver; Nürnberger, Andreas; Pathiraja, Sahani

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 0810

Abstract

Simulation and comparison of transmit elements for 7T head-imaging with a large diameter transmit coil

Hubmann, Max Joris; Kowal, Robert; Orzada, Stephan; Wagner, Piet; Seifert, Frank; Speck, Oliver; Maune, Holger

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 4583

Abstract

FAIR benchmarking of 7T MRI antennas - case for a standardized protocol for RF transmit element performance assessment

Hubmann, Max Joris; Nurzed, Bilguun; Niendorf, Thoralf; Speck, Oliver; Maune, Holger

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 4242

Abstract

Complex-valued fourier primal-dual - undersampled MRI reconstruction in hybrid-space

Chatterjee, Soumick; Ernst, Philipp; Speck, Oliver; Nürnberger, Andreas

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 4955

Abstract

The potential of ultra-high resolution 7T T2-weighted TSE to assess the glymphatic system’s structure

Mattern, Hendrik; Speck, Oliver

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 3180

Abstract

Addressing electromagnetic interference during MR-guided ablations

Schröer, Simon; Löning Caballero, Joseph Joaquin; Düx, Daniel Markus; Glandorf, Julian; Gerlach, Thomas; Wacker, Frank; Speck, Oliver

In: Konferenz: 6th Conference on Image-Guided Interventions, IGIC 2023, Mannheim, 19-20 October 2023, 6th Conference on Image-Guided Interventions - Mannheim . - 2023, S. 38

Abstract

Altered resting-state fMRI BOLD signal fluctuations in the spectrum of Alzheimer’s dementia and in patients with white matter hyperintensities

Behrenbruch, Niklas; Incesoy, Enise I.; Bernal, Jose; Menze, Inga; Vockert, Niklas; Kleineidam, Luca; Buerger, Katharina; Wolfsgruber, Steffen; Spottke, Annika; Fließbach, Klaus; Laske, Christoph; Perneczky, Robert; Peters, Oliver Hubertus; Priller, Josef; Schneider, Anja; Heneka, Michael Thomas; Wagner, Michael; Teipel, Stefan; Wiltfang, Jens; Speck, Oliver; Perosa, Valentina; Yakupov, Renat; Jessen, Frank; Düzel, Emrah; Mattern, Hendrik; Schreiber, Stefanie; Ziegler, Gabriel; Maass, Anne

In: Alzheimer's and dementia - Hoboken, NJ : Wiley, Bd. 19 (2023), Heft Suppl. 16, Artikel e078315, insges. 5 S.

Abstract

Distortion correction at ultrahigh field: Benefit of deviation from ‘‘best’’ VAT

Tung, Yi-Hang; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 36 (2023), S. S64-S65

Abstract

Markerless monocular head tracking for pediatric MRI

Bartsch, L.; Röll, S.; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 36 (2023), S. S129-S130

Abstract

Predicting image quality from k-space aware motion detection

Bartsch, L.; Röll, S.; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 36 (2023), S. S133-S134

Abstract

Enabling in vivo assessment of motor cortex vessel dominance patterns using 7T MRI and vessel distance mapping

Mietzner, Grazia; Schreiber, Frank; Lümkemann, Lilli; Brüggemann, Jascha; Sciarra, Alessandro; Knoll, Christoph; Kühn, Esther; Speck, Oliver; Schreiber, Stefanie; Mattern, Hendrik

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 36 (2023), Heft Suppl. 1, S. S213-S214, Artikel P175 [Meeting: ESMRMB 2023 online, 39th Annual Scientific Meeting, 4-7 October 2023]

Abstract

Curvature adapted Wireless Metasurface Resonators for MR-guided Interventions

Knull, Lucas; Kowal, Robert; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Maune, Holger

In: Konferenz: 6th Conference on Image-Guided Interventions, IGIC 2023, Mannheim, 19-20 October 2023, 6th Conference on Image-Guided Interventions - Mannheim . - 2023, S. 61-62

Abstract

FAIR benchmarking of 7T MRI antennas - case for a standardized protocol for RF transmit element performance assessment

Hubmann, Max Joris; Nurzed, Bildgun; Niendorf, Thoralf; Speck, Oliver; Maune, Holger

In: ISMRM & ISMRT Annual Meeting & Exhibition - Concord, CA : International Society for Magnetic Resonance in Medicine . - 2023, Artikel 4242

Book chapter

Complex network for complex problems - a comparative study of CNN and Complex-valued CNN

Chatterjee, Soumick; Tummala, Pavan; Speck, Oliver; Nürnberger, Andreas

In: 2022 IEEE 5th International Image Processing, Applications and Systems Conference / IEEE International Conference on Image Processing Applications and Systems , 2022 - [Piscataway, NJ] : IEEE . - 2023, insges. 5 S.

Book chapter

Liver segmentation in time-resolved C-arm CT volumes reconstructed from dynamic perfusion scans using time separation technique

Chatterjee, Soumick; Haseljić, Hana; Frysch, Robert; Kulvait, Vojtěch; Semshchikov, Vladimir; Hensen, Bennet; Wacker, Frank; Brüsch, Inga; Werncke, Thomas; Speck, Oliver; Nürnberger, Andreas; Rose, Georg

In: 2022 IEEE 5th International Image Processing, Applications and Systems Conference / IEEE International Conference on Image Processing Applications and Systems , 2022 - [Piscataway, NJ] : IEEE . - 2023, insges. 7 S.

Peer-reviewed journal article

It is the locus coeruleus! Or… is it? - a proposition for analyses and reporting standards for structural and functional magnetic resonance imaging of the noradrenergic locus coeruleus

Yi, Yeo-Jin; Lüsebrink-Rindsland, Jann Falk Silvester; Ludwig, Mareike; Maaß, Anne; Ziegler, Gabriel; Yakupov, Renat; Kreißl, Michael; Betts, Matthew TJ; Speck, Oliver; Düzel, Emrah; Hämmerer, Dorothea

In: Neurobiology of aging - Amsterdam [u.a.] : Elsevier Science, Bd. 129 (2023), S. 137-148

Peer-reviewed journal article

Vessel distance mapping - a novel methodology for assessing vascular-induced cognitive resilience

Garcia-Garcia, Berta; Mattern, Hendrik; Vockert, Niklas; Yakupov, Renat; Schreiber, Frank; Spallazzi, Marco; Perosa, Valentina; Haghikia, Aiden; Speck, Oliver; Düzel, Emrah; Maass, Anne; Schreiber, Stefanie

In: NeuroImage - Orlando, Fla. : Academic Press, Bd. 274 (2023), Artikel 120094, insges. 12 S.

Peer-reviewed journal article

Study protocol - value of 7-T MRI with prospective motion correction and postprocessing for patients with nonlesional epilepsy - Studienprotokoll - Wert der 7-T-MRT mit prospektiver Bewegungskorrektur und Nachbearbeitung bei Patienten mit nichtläsionaler Epilepsie

Kukhlenko, Olga; Kukhlenko, Rostyslav; Tempelmann, Claus; Speck, Oliver; Hinrichs, Hermann; Heinze, Hans-Jochen; Heers, Marcel; House, Patrick M.; Wörmann, Friedrich Gerrit; Knake, Susanne; Urbach, Horst; Huppertz, Hans-Jürgen; Haghikia, Aiden; Schmitt, Friedhelm C.

In: Clinical epileptology - Berlin : Springer Medizin Verlag GmbH, Bd. 36 (2023), Heft 4, S. 320-326

Peer-reviewed journal article

Reduced dimension stimulus decoding and column-based modeling reveal architectural differences of primary somatosensory finger maps between younger and older adults

Kalyani, Avinash; Contier, Oliver; Klemm, Lisa; Azañon, Elena; Schreiber, Stefanie; Speck, Oliver; Reichert, Christoph; Kühn, Esther

In: NeuroImage - Orlando, Fla. : Academic Press, Bd. 283 (2023), Artikel 120430, insges. 13 S.

Peer-reviewed journal article

Towards an integrated radiofrequency safety concept for implant carriers in MRI based on sensor-equipped implants and parallel transmission

Petzold, Johannes; Schmitter, Sebastian; Silemek, Berk; Winter, Lukas; Speck, Oliver; Ittermann, Bernd; Seifert, Frank

In: NMR in biomedicine - New York, NY : Wiley, Bd. 36 (2023), Heft 7, Artikel e4900, insges. 20 S.

Peer-reviewed journal article

Germany’s journey toward 14 Tesla human magnetic resonance

Ladd, Mark E.; Quick, Harald H.; Speck, Oliver; Bock, Michael; Doerfler, Arnd; Forsting, Michael; Hennig, Jürgen; Ittermann, Bernd; Möller, Harald E.; Nagel, Armin M.; Niendorf, Thoralf; Remy, Stefan; Schaeffter, Tobias; Scheffler, Klaus; Schlemmer, Heinz-Peter; Schmitter, Sebastian; Schreiber, Laura M.; Shah, N. Jon; Stöcker, Tony; Uder, Michael; Villringer, Arno; Weiskopf, Nikolaus; Zaiss, Moritz; Zaitsev, Maxim

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 36 (2023), Heft 2, S. 191-200

Peer-reviewed journal article

Investigation of alternative RF power limit control methods for 0.5T, 1.5T, and 3T parallel transmission cardiac imaging - a simulation study

Petzold, Johannes; Schmitter, Sebastian; Silemek, Berk; Winter, Lukas; Speck, Oliver; Ittermann, Bernd; Seifert, Frank

In: Magnetic resonance in medicine - New York, NY [u.a.] : Wiley-Liss . - 2023, insges. 17 S.

Peer-reviewed journal article

Counteraction of inflammatory activity in CAA-related subarachnoid hemorrhage

Schreiber, Stefanie; John, Anna-Charlotte; Werner, Cornelius Johannes; Vielhaber, Stefan; Heinze, Hans-Jochen; Speck, Oliver; Würfel, Jens Thomas; Behme, Daniel; Mattern, Hendrik

In: Journal of neurology - [Darmstadt] : Steinkopff, Bd. 270 (2023), Heft 2, S. 1159-1161

Peer-reviewed journal article

Cerebral small vessel disease burden and cognitive and functional outcomes after stroke - a multicenter prospective cohort study

Georgakis, Marios K.; Fang, Rong; Düring, Marco; Wollenweber, Frank Arne; Bode, Felix J.; Stösser, Sebastian; Kindlein, Christine; Hermann, Peter; Liman, Thomas; Nolte, Christian H.; Kerti, Lucia; Ikenberg, Benno; Bernkopf, Kathleen; Poppert, Holger; Glanz, Wenzel; Perosa, Valentina; Janowitz, Daniel; Wagner, Michael; Neumann, Katja; Speck, Oliver; Dobisch, Laura; Düzel, Emrah; Gesierich, Benno; Dewenter, Anna; Spottke, Annika E.; Waegemann, Karin; Görtler, Michael; Wunderlich, Silke; Endres, Matthias; Zerr, Inga; Petzold, Gabor; Dichgans, Martin

In: Alzheimer's and dementia - Hoboken, NJ : Wiley, Bd. 19 (2023), Heft 4, S. 1152-1163

Peer-reviewed journal article

Liver segmentation using turbolift learning for CT and cone-beam C-arm perfusion imaging

Haseljić, Hana; Chatterjee, Soumick; Frysch, Robert; Kulvait, Vjtěch; Semshchikov, Vladimir; Hensen, Bennet; Wacker, Frank; Brüsch, Inga; Werncke, Thomas; Speck, Oliver; Nürnberger, Andreas; Rose, Georg

In: Computers in biology and medicine - Amsterdam [u.a.] : Elsevier Science, Bd. 154 (2023), Artikel 106539

Peer-reviewed journal article

The 3D structural architecture of the human hand area is nontopographic

Doehler, Juliane; Northall, Alicia; Liu, Peng; Fracasso, Alessio; Chrysidou, Anastasia; Speck, Oliver; Lohmann, Gabriele; Wolbers, Thomas; Kühn, Esther

In: The journal of neuroscience - Washington, DC : Soc., Bd. 43 (2023), Heft 19, S. 3456-3476

Peer-reviewed journal article

MR based magnetic susceptibility measurements of 3D printing materials at 3 Tesla

Sangal, Maitreyi; Anikeeva, Mariia; Priese, Simon C.; Mattern, Hendrik; Hövener, Jan-Bernd; Speck, Oliver

In: SSRN eLibrary - [Erscheinungsort nicht ermittelbar] : Social Science Electronic Publ. . - 2023, insges. 17 S.

Peer-reviewed journal article

Cross-sectional study of retrospective self-reported childhood emotional neglect and inhibitory neurometabolite levels in the pregenual anterior cingulate cortex in adult humans

Herrmann, Luisa; Ade, Johanna; Kühnel, Anne; Widmann, Annina; Demenescu, Liliana Romona; Li, Meng; Opel, Nils; Speck, Oliver; Walter, Martin; Colic, Lejla

In: Neurobiology of Stress - Amsterdam [u.a.] : Elsevier, Bd. 25 (2023), Artikel 100556

Peer-reviewed journal article

MICDIR - multi-scale inverse-consistent deformable image registration using UNetMSS with self-constructing graph latent

Chatterjee, Soumick; Bajaj, Himanshi; Siddiquee, Istiyak H.; Subbarayappa, Nandish Bandi; Simon, Steve; Shashidhar, Suraj Bangalore; Speck, Oliver; Nürnberger, Andreas

In: Computerized medical imaging and graphics - Amsterdam [u.a.] : Elsevier Science, Bd. 108 (2023), Artikel 102267

Peer-reviewed journal article

Sinogram upsampling using Primal-Dual UNet for undersampled CT and radial MRI reconstruction

Ernst, Philipp; Chatterjee, Soumick; Rose, Georg; Speck, Oliver; Nürnberger, Andreas

In: Neural networks - Amsterdam : Elsevier, Bd. 166 (2023), S. 704-721

Peer-reviewed journal article

Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Danyeli, Lena; Şen, Zümrüt Duygu; Colic, Lejla; Kurzweil, Lisa; Gensberger-Reigl, Sabrina; Macharadze, Tamar; Götting, Florian Nicolas; Refisch, Alexander; Liebe, Thomas; Chand, Tara; Kretzschmar, Moritz Andreas; Wagner, Gerd; Opel, Nils; Jollant, Fabrice; Speck, Oliver; Munk, Matthias Hans Joachim; Li, Meng; Walter, Martin

In: Translational Psychiatry - London : Nature Publishing Group, Bd. 13 (2023), Artikel 60, insges. 9 S.

Peer-reviewed journal article

Magnetic resonance imaging and velocimetry of ethane

Anikeeva, Maria; Sangal, Maitreyi; Pravdivtsev, Andrey N.; Pravdivtseva, Maryia S.; Peschke, Eva; Speck, Oliver; Hövener, Jan-Bernd

In: Journal of magnetic resonance open - Amsterdam : Elsevier, Bd. 16/17 (2023), Artikel 100137

Peer-reviewed journal article

Cognitive training, but not EEG-neurofeedback, improves working memory in healthy volunteers

Barbazzeni, Beatrice; Speck, Oliver; Düzel, Emrah

In: Brain communications - [Oxford] : Oxford University Press, Bd. 5 (2023), Heft 2, Artikel fcad101, insges. 17 S.

Dissertation

Improving thermal cancer treatment with 2D to 3D heat map reconstruction

Alpers, Julian; Hansen, Christian; Speck, Oliver

In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Informatik 2023, 1 Online-Ressource (xiv, 139 Seiten, 2,34 MB) [Literaturverzeichnis: Seite 125-136][Literaturverzeichnis: Seite 125-136]

Dissertation

Towards faster and more precise MR spectroscopy at 7 T

Riemann, Layla Tabea; Rose, Georg; Speck, Oliver

In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektro- und Informationstechnik 2023, 1 Online-Ressource (XII, 76, XIII-XXIII Seiten, 40,26 MB) [Literaturverzeichnis: Seite XIII-XXIII][Literaturverzeichnis: Seite XIII-XXIII]

Article in conference proceedings

Enhancing vessel continuity in deep learning based segmentation using maximum intensity projection as loss

Chatterjee, Soumick; Chintalapati, Karthikesh Varma; Radhakrishna, Chethan; Hudukula Ram Kumar, Sri Chandana; Sutrave, Raviteja; Mattern, Hendrik; Speck, Oliver; Nürnberger, Andreas

In: ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2023, insges. 4 S. [Konferenz: ISMRM 2023, Toronto, Canada, June 2023]

Article in conference proceedings

Exploiting the inter-rater disagreement to improve probabilistic segmentation

Chatterjee, Soumick; Schulz, Franziska; Sciarra, Alexandro; Mattern, Hendrik; Janiga, Gábor; Speck, Oliver; Nürnberger, Andreas; Pathiraja, Sahani

In: Konferenz: ISMRM 2023, Toronto, Canada, June 2023, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2023, insges. 4 S.

Article in conference proceedings

Complex-valued fourier primal-dual - undersampled MRI reconstruction in hybrid-space

Chatterjee, Soumick; Ernst, Philipp; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ISMRM 2023, Toronto, Canada, June 2023, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2023, insges. 3 S.

Non-peer-reviewed journal article

Correction: Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Danyeli, Lena; Şen, Zümrüt Duygu; Colic, Lejla; Kurzweil, Lisa; Gensberger-Reigl, Sabrina; Macharadze, Tamar; Götting, Florian Nicolas; Refisch, Alexander; Liebe, Thomas; Chand, Tara; Kretzschmar, Moritz Andreas; Wagner, Gerd; Opel, Nils; Jollant, Fabrice; Speck, Oliver; Munk, Matthias Hans Joachim; Li, Meng; Walter, Martin

In: Translational Psychiatry - London : Nature Publishing Group, Bd. 13 (2023), Artikel 73, insges. 1 S.

2022

Abstract

Reduction of electromagnetic interferences of a commercially available MR approved microwave generator

Löning, Joaquin; Meyer-zu-Hartlage, Karen; Gerlach, Thomas; Speck, Oliver; Hensen, Bennet; Gutberlet, Marcel

In: 13th International Interventional MRI Symposium - Leipzig, 2022 . - 2022, S. 125

Abstract

On the interactions between glymphatic system, neuroinflammation and cortical superficial siderosis - a case study

John, Anna-Charlotte; Schreiber, Stefanie; Werner, Cornelius Johannes; Vielhaber, Stefan; Heinze, Hans-Jochen; Speck, Oliver; Würfel, Jens Thomas; Behme, Daniel; Mattern, Hendrik

In: 8th International CAA Conference - International CAA Association, 2022 . - 2022

Abstract

Evolution of cortical superficial siderosis in a 75-year-old patient with cerebral amyloid angiopathy

John, Anna-Charlotte; Schreiber, Stefanie; Werner, Cornelius Johannes; Vielhaber, Stefan; Heinze, Hans-Jochen; Speck, Oliver; Würfel, Jens Thomas; Behme, Daniel; Mattern, Hendrik

In: 8th International CAA Conference - International CAA Association, 2022 . - 2022

Abstract

Entwicklung einer kortikalen superfiziellen Siderose bei einer 75-jährigen Patientin mit zerebraler Amyloidangiopathie

John, Anna-Charlotte; Schreiber, Stefanie; Werner, Cornelius Johannes; Vielhaber, Stefan; Heinze, Hans-Jochen; Speck, Oliver; Würfel, Jens Thomas; Behme, Daniel; Mattern, Hendrik

In: 57. Jahrestagung der Deutschen Gesellschaft für Neuroradiologie, Neurorad 2022 - Kassel, 2022 . - 2022

Abstract

Vessel distance mapping - a novel methodology for assessing vascular-induced cognitive resilience

Garcia-Garcia, Berta; Mattern, Hendrik; Vockert, Niklas; Yakupov, Renat; Schreiber, Frank; Spallazzi, Marco; Perosa, Valentina; Speck, Oliver; Düzel, Emrah; Maass, Anne; Schreiber, Stefanie

In: Alzheimer's Association International Conference - Alzheimer's Association, 2022 . - 2022

Abstract

Magnetic resonance relaxometry and susceptibility of contemporary 3D printing materials

Anikeeva, M.; Sabgal, Maitreyi; Pravdivtseva, M. S.; Mattern, Hendrik; Speck, Oliver; Hövener, J.-B.

In: International Workshop on Reacting Particle-Gas Systems 2022 - Bochum, 2022 . - 2022

Abstract

Resolution-dependency of arterial and venous density estimates and vessel distance maps in deep gray matter

Mattern, Hendrik; Speck, Oliver

In: London bound 2022 - International Society for Magnetic Resonance in Medicine, 2022 . - 2022

Abstract

Development of Freely Available 3D Radial Gradient Echo Sequences and Reconstruction; 13th Annual Scientific Symposium Ultrahigh Field Magnetic Resonance. September 2022, Berlin

Velasquez Vides, J.R.; Speck, Oliver; Niendorf, T.; Mattern, Hendrik

In: ., S. .

Abstract

Application of litz wires in MRI coil design up to 15 MHz

Kowal, Robert; Fomin, Ivan; Prier, Marcus; Pannicke, Enrico; Rose, Georg; Speck, Oliver

In: London bound 2022 - International Society for Magnetic Resonance in Medicine, 2022 . - 2022

Abstract

Metamaterial inspired surface resonators as wireless coil

Kowal, Robert; Knull, Lucas; Pannicke, Enrico; Hubmann, Max Joris; Fomin, Ivan; Gareis, Daniel; Scherbel, Selina; Hensen, Bennet; Rose, Georg; Wacker, Frank; Speck, Oliver

In: 13th International Interventional MRI Symposium - Leipzig, 2022 . - 2022, S. 106

Abstract

Multi-channel receive coil for MRI-guided interventions

Kowal, Robert; Pannicke, Enrico; Gareis, Daniel; Scherbel, Selina; Knull, Lucas; Fomin, Ivan; Hubmann, Max Joris; Hensen, Bennet; Rose, Georg; Wacker, Frank; Speck, Oliver

In: Symposium: 13th Interventional MRI Symposium 2022, Leipzig, October 14-15, 2022, 13th International Interventional MRI Symposium - Leipzig . - 2022, S. 107

Abstract

Intensity-based tracking technique to register devices in MRI-guided procedures

Fomin, Ivan; Kowal, Robert; Gutberlet, Marcel; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Rose, Georg

In: 13th Interventional MRI Symposium - Leipzig, 2022 . - 2022, S. 51

Abstract

Development of a low-cost B0 field mapping device

Eisenmann, Marcel; Fomin, Ivan; Prier, Marcus; Rose, Georg; Speck, Oliver

In: London bound 2022 - International Society for Magnetic Resonance in Medicine, 2022 . - 2022

Book chapter

Prior-aided volume of interest CBCT image reconstruction for clinical interventional data

Punzet, Daniel; Frysch, Robert; Behme, Daniel; Pfeiffer, Tim; Speck, Oliver; Rose, Georg

In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 12031 (2022), Artikel 1203127

Book chapter

A real-time energy monitoring system for an MRI hybrid ablation system

Gerlach, Thomas; Shaik, Nashwa; Hubmann, Max Joris; Prier, Marcus; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: 44rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , 2022 - [Piscataway, NJ] : IEEE, S. 5016-5020

Book chapter

High resolution structural brain imaging

Mattern, Hendrik; Lüsebrink-Rindsland, Jann Falk Silvester; Speck, Oliver

In: Motion Correction in MR - San Diego: Elsevier Science & Technology; Kouwe, Andre . - 2022

Peer-reviewed journal article

Amyloid pathology but not APOE [epsilon]4 status is permissive for tau-related hippocampal dysfunction

Düzel, Emrah; Ziegler, Gabriel; Berron, David; Maass, Anne; Schütze, Hartmut; Cardenas-Blanco, Arturo; Glanz, Wenzel; Metzger, Coraline Danielle; Dobisch, Laura; Reuter, Martin; Spottke, Annika E.; Brosseron, Frederic; Fliessbach, Klaus; Heneka, Michael Thomas; Laske, Christoph; Peters, Oliver Hubertus; Priller, Josef; Spruth, Eike Jakob; Ramírez, Alfredo; Speck, Oliver; Schneider, Anja; Teipel, Stefan; Kilimann, Ingo; Wiltfang, Jens; Schott, Björn H.; Preis, Lukas; Gref, Daria; Maier, Franziska; Munk, Matthias Hans Joachim; Roy, Nina; Ballarini, Tommaso; Yakupov, Renat; Haynes, John-Dylan; Dechent, Peter; Scheffler, Klaus; Wagner, Michael; Jessen, Frank

In: Brain - Oxford : Oxford Univ. Press, Bd. 145 (2022), Heft 4, S. 1473-1485

Peer-reviewed journal article

Nichtinvasive funktionelle Lungenbildgebung mit hyperpolarisiertem Xenon - Noninvasive functional lung imaging with hyperpolarized xenon

Anikeeva, Mariia; Sangal, Maitreyi; Speck, Oliver; Norquay, Graham; Zuhayra, Maaz; Lützen, Ulf; Peters, Josh; Jansen, Olav; Hövener, Jan-Bernd

In: Die Radiologie - [Berlin] : Springer Medizin Verlag GmbH, Bd. 62 (2022), Heft 6, S. 475-485

Peer-reviewed journal article

The differential association between local neurotransmitter levels and whole-brain resting-state functional connectivity in two distinct cingulate cortex subregions

Li, Meng; Danyeli, Lena; Colic, Lejla; Wagner, Gerd; Smesny, Stefan; Chand, Tara; Di, Xin; Biswal, Bharat B.; Kaufmann, Jörn; Reichenbach, Jürgen; Speck, Oliver; Walter, Martin; Sen, Zümrüt Duygu

In: Human brain mapping - New York, NY : Wiley-Liss, Bd. 43 (2022), Heft 9, S. 2833-2844

Peer-reviewed journal article

Rapid geometry-corrected echo-planar diffusion imaging at ultrahigh field - fusing view angle tilting and point-spread function mapping

Tung, Yi-Hang; In, Myung-Ho; Ahn, Sinyeob; Speck, Oliver

In: Magnetic resonance in medicine - New York, NY [u.a.]: Wiley-Liss, Bd. 88 (2022), 5, S. 2074-2087

Peer-reviewed journal article

Fourier-based decomposition for simultaneous 2-voxel MRS acquisition with 2SPECIAL

Riemann, Layla Tabea; Aigner, Christoph Stefan; Mekle, Ralf; Speck, Oliver; Rose, Georg; Ittermann, Bernd; Schmitter, Sebastian; Fillmer, Ariane

In: Magnetic resonance in medicine - New York, NY [u.a.]: Wiley-Liss, Bd. 88 (2022), 5, S. 1978-1993

Peer-reviewed journal article

The impact of respiratory motion on electromagnetic fields and specific absorption rate in cardiac imaging at 7T

Schoen, Natalie; Seifert, Frank; Petzold, Johannes; Metzger, Gregory J.; Speck, Oliver; Rose, Georg; Ittermann, Bernd; Schmitter, Sebastian

In: Magnetic resonance in medicine - New York, NY [u.a.]: Wiley-Liss, Bd. 88 (2022), 6, S. 2645-2661

Peer-reviewed journal article

StRegA - unsupervised anomaly detection in brain MRIs using a compact context-encoding variational autoencoder

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Tummala, Pavan; Agrawal, Shubham Kumar; Jauhari, Aishwarya; Kalra, Aman; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: Computers in biology and medicine - Amsterdam [u.a.]: Elsevier Science, Bd. 149 (2022)

Peer-reviewed journal article

DS6, deformation-aware semi-supervised learning - application to small vessel segmentation with noisy training data

Chatterjee, Soumick; Prabhu, Kartik; Pattadkal, Mahantesh; Bortsova, Gerda; Sarasaen, Chompunuch; Dubost, Florian; Mattern, Hendrik; Bruijne, Marleen; Speck, Oliver; Nürnberger, Andreas

In: Journal of imaging - Basel : MDPI, Bd. 8 (2022), Heft 10, Artikel 259, insges. 22 S.

Peer-reviewed journal article

Characterization of shear zones in soft granular beds by means of a novel magnetic resonance imaging technique

Wang, Jing; Farmani, Zohreh; Dijksman, Joshua A.; Lübeck, Cindy; Speck, Oliver; Stannarius, Ralf

In: Granular matter - Berlin: Springer, Bd. 24 (2022), insges. 13 S.

Peer-reviewed journal article

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann, Saskia; Mattern, Hendrik; Bernier, Michael; Robinson, Simon D.; Park, Daniel; Speck, Oliver; Polimeni, Jonathan R.

In: eLife - Cambridge: eLife Sciences Publications, Bd. 11 (2022), insges. 35 S.

Peer-reviewed journal article

Quantitative evaluation of prospective motion correction in healthy subjects at 7T MRI

Sciarra, Alessandro; Mattern, Hendrik; Yakupov, Renat; Chatterjee, Soumick; Stucht, Daniel; Oeltze-Jafra, Steffen; Godenschweger, Frank; Speck, Oliver

In: Magnetic resonance in medicine - New York, NY [u.a.]: Wiley-Liss, 1984, Bd. 87 (2022), 2, S. 646-657

Peer-reviewed journal article

Pulsatility index in the basal ganglia arteries increases with age in elderly with and without cerebral small vessel disease

Perosa, Valentina; Arts, Tine; Assmann, Anne; Mattern, Hendrik; Speck, Oliver; Oltmer, Jan; Heinze, Hans-Jochen; Düzel, Emrah; Schreiber, Stefanie; Zwanenburg, Jaco J. M.

In: American journal of neuroradiology - Oak Brook, Ill. : Soc., Bd. 43 (2022), Heft 4, S. 540-546

Peer-reviewed journal article

ReconResNet: Regularised residual learning for MR image reconstruction of undersampled cartesian and radial data

Chatterjee, Soumick; Breitkopf, Mario; Sarasaen, Chompunuch; Yassin, Hadya; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: Computers in biology and medicine - Amsterdam [u.a.] : Elsevier Science, Bd. 143 (2022), Artikel 105321

Peer-reviewed journal article

TorchEsegeta - framework for interpretability and explainability of image-based deep learning models

Chatterjee, Soumick; Das, Arnab; Mandal, Chirag; Mukhopadhyay, Budhaditya; Vipinraj, Manish; Shukla, Aniruddh; Nagaraja Rao, Rajatha; Sarasaen, Chompunuch; Speck, Oliver; Nürnberger, Andreas

In: Applied Sciences - Basel : MDPI, Bd. 12 (2022), Heft 4, Artikel 1834, insges. 20 S.

Peer-reviewed journal article

Classification of brain tumours in MR images using deep spatiospatial models

Chatterjee, Soumick; Nizamani, Faraz Ahmed; Nürnberger, Andreas; Speck, Oliver

In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 12 (2022), insges. 11 S.

Dissertation

Reducing artefacts in MRI using Deep Learning - enhancing automatic image processing pipelines

Chatterjee, Soumick; Nürnberger, Andreas; Speck, Oliver

In: Magdeburg, 2022, xxv, 360 Seiten, Illustrationen, Diagramme, 30 cm

Article in conference proceedings

DDoS-UNet - incorporating temporal information using dynamic dual-channel UNet for enhancing super-resolution of dynamic MRI

Chatterjee, Soumick; Serasaen, Chompunuch; Rose, Georg; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: Medical Imaging with Deep Learning (MIDL), Zürich, 2022, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2022, insges. 4 S.

Article in conference proceedings

Automated SSIM regression for detection and quantification of motion artefacts in brain MR images

Sciarra, Alessandro; Chatterjee, Soumick; Dünnwald, Max; Placidi, Giuseppe; Nürnberger, Andreas; Speck, Oliver; Oeltze-Jafra, Steffen

In: Konferenz: Medical Imaging with Deep Learning (MIDL), Zürich, 2022, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp., 2010 . - 2022, insges. 10 S.

Article in conference proceedings

Reference-less SSIM Regression for Detection and Quantification of Motion Artefacts in Brain MRIs

Sciarra, Alessandro; Chatterjee, Soumick; Dünnwald, Max; Placidi, Giuseppe; Nürnberger, Andreas; Speck, Oliver; Oeltze-Jafra, Steffen

In: Konferenz: Medical Imaging with Deep Learning (MIDL), Zürich, 2022, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2022, insges. 4 S.

Article in conference proceedings

StRegA - unsupervised anomaly detection in brain MRIs using compact context-encoding variational autoencoder

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Tummala, Pavan; Agrawal, Shubham; Jauhari, Aishwarya; Kalra, Aman; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ISMRM-ESMRMB 2022, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp., 2010 . - 2022, insges. 4 S.

Article in conference proceedings

Learning to segment brain tumours using an explainable classifier

Chatterjee, Soumick; Yassin, Hadya; Dubost, Florian; Nürnberger, Andreas; Speck, Oliver

In: Konferenz: ISMRM-ESMRMB 2022, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2022, insges. 4 S.

Article in conference proceedings

Motion-robust dynamic abdominal MRI using k-t GRASP and dynamic dual-channel training of super-resolution U-Net (DDoS-UNet)

Sarasaen, Chompunuch; Chatterjee, Soumick; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: Konferenz: ISMRM-ESMRMB 2022, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2022, insges. 4 S.

Article in conference proceedings

Multi-scale UNet with self-constructing graph latent for deformable image registration

Chatterjee, Soumick; Bajaj, Himanshi; Hossain Siddiquee, Mohammad Istiyak; Bandi Subbarayappa, Nandish; Simon, Steve; Shashidhar, Suraj; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ISMRM-ESMRMB 2022, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2022, insges. 4 S.

Article in conference proceedings

Uncertainty quantification for ground-truth free evaluation of deep learning reconstructions

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Talagini Ashoka, Anitha Bhat; Cheepinahalli Vasudeva, Mayura Gurjar; Saravanan, Shudarsan; Sambandham, Venkatesh Thirugnana; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ISMRM-ESMRMB 2022, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp., 2010 . - 2022, insges. 4 S.

Non-peer-reviewed journal article

Weakly-supervised segmentation using inherently-explainable classification models and their application to brain tumour classification

Chatterjee, Soumick; Yassin, Hadya; Dubost, Florian; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.] : Arxiv.org . - 2022, Artikel 2206.05148, insges. 14 S.

Non-peer-reviewed journal article

Automated SSIM regression for detection and quantification of motion artefacts in brain MR images

Sciarra, Alessandro; Chatterjee, Soumick; Dünnwald, Max; Placidi, Giuseppe; Nürnberger, Andreas; Speck, Oliver; Oeltze-Jafra, Steffen

In: De.arxiv.org - [S.l.]: Arxiv.org, 1991 . - 2022, insges. 9 S.

Non-peer-reviewed journal article

MICDIR - multi-scale Inverse-consistent deformable image registration using UNetMSS with self-constructing graph latent

Chatterjee, Soumick; Bajaj, Himanshi; Siddiquee, Istiyak H.; Subbarayappa, Nandish Bandi; Simon, Steve; Shashidhar, Suraj Bangalore; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.] : Arxiv.org . - 2022, Artikel 2203.04317, insges. 19 S.

Non-peer-reviewed journal article

StRegA - unsupervised anomaly detection in brain MRIs using a compact context-encoding variational autoencoder

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Tummala, Pavan; Agrawal, Shubham Kumar; Jauhari, Aishwarya; Kalra, Aman; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.]: Arxiv.org, 1991 . - 2022, insges. 13 S.

Non-peer-reviewed journal article

DDoS-UNet - incorporating temporal information using dynamic dual-channel UNet for enhancing super-resolution of dynamic MRI

Chatterjee, Soumick; Sarasaen, Chompunuch; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: De.arxiv.org - [S.l.] : Arxiv.org . - 2022, Artikel 2202.05355, insges. 12 S.

Non-peer-reviewed journal article

Liver segmentation using turbolift learning for CT and cone-beam C-arm perfusion imaging

Haseljić, Hana; Chatterjee, Soumick; Frysch, Robert; Kulvait, Vojtěch; Semshchikov, Vladimir; Hensen, Bennet; Wacker, Frank; Brüsch, Inga; Werncke, Thomas; Speck, Oliver; Nürnberger, Andreas; Rose, Georg

In: De.arxiv.org - [S.l.] : Arxiv.org . - 2022, Artikel 2207.10167, insges. 16 S.

2021

Abstract

Educational tabletop MRI system using the open-source console for real-time acquisition (OCRA)

Prier, Marcus; Schote, David; Fomin, Ivan; Witzel, Thomas; Rose, Georg; Speck, Oliver

In: ISMRM & SMRT Annual Meeting and Exhibition$an online experience : 15-20 May 2021 - Concord, CA: International Society for Magnetic Resonance in Medicine, 2021 . - 2021

Abstract

Combining receive coils with microposition robotics for MRI guided interventions

Fomin, Ivan; Kowal, Robert; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Rose, Georg

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 27-28

Abstract

Vaskuläre Ursachen kognitiver Defizite bei Patienten mit zerebraler Mikroangiopathie

Neumann, K.; Aruci, M.; Aki, C.; Günther, M.; Mistelbauer, G.; Garcia-Garcia, Berta; Oeltze-Jafra, Steffen; Stucht, Daniel; Mattern, Hendrik; Speck, Oliver; Perosa, Valentina; Düzel, Emrah; Schreiber, Stefanie

In: Research Days 2021 - Magdeburg, 2021 . - 2021

Abstract

Flexible split-coil design for various field strengths

Kowal, Robert; Pannicke, Enrico; Prier, Marcus; Ehses, Mai; Rose, Georg; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg: Springer, 1993, Volume 34(2021), Suppl. 1, Seite S37

Abstract

Comparison of SNR between a low-field (0.26T) Tabletop-MRI and a clinical high-field (3T) scanner

Kowal, Robert; Pannicke, Enrico; Prier, Marcus; Vick, Ralf; Rose, Georg; Speck, Oliver

In: ISMRM & SMRT Annual Meeting and Exhibition$an online experience : 15-20 May 2021 - Concord, CA: International Society for Magnetic Resonance in Medicine, 2021 . - 2021

Abstract

Feasibility study of MRI-guided IRE

Hubmann, Max Joris; Gerlach, Thomas; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 21-22

Abstract

MRI safety evaluation of flexible coil

Ehses, Maik; Pannicke, Enrico; Sánchez López, Juan Sebastián; Scherbel, Selina; Kowal, Robert; Hensen, Bennet; Wacker, Frank; Rose, Georg; Speck, Oliver

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 79-80

Abstract

Disposable receive coils for MR-guided interventions

Kowal, Robert; Sánchez López, Juan Sebastián; Pannicke, Enrico; Ehses, Maik; Moritz, Julia; Scherbel, Selina; Hensen, Bennet; Becker, Mathias; Fischbach, Frank; Pech, Maciej; Wacker, Frank; Rose, Georg; Speck, Oliver

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 25-26

Abstract

Virtual reality-based usability laboratory for interventional MR applications

Kwapik, Remigiusz; Moritz, Julia; Hensen, Bennet; Janny, Benedikt; Pannicke, Enrico; Schott, Danny; Rose, Georg; Speck, Oliver; Wacke, Frank

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 51-52

Abstract

Robustness evaluation of grangeat registration for prior-based reconstruction

Punzet, Daniel; Frysch, Robert; Behme, Daniel; Speck, Oliver; Rose, Georg

In: Konferenz: 5th Conference on Image-Guided Interventions, IGIC 2021, Magdeburg, 13-14 October 2021, 5th Conference on Image-Guided Interventions (IGIC) , 2021 - Magdeburg : [Otto-von-Guericke University Magdeburg] ; Hansen, Christian *1980-*, S. 7

Abstract

Vessel distance mapping for deep gray matter structures

Mattern, Hendrik; Schreiber, Stefanie; Speck, Oliver

In: ISMRM & SMRT Annual Meeting and Exhibition - Concord, CA: International Society for Magnetic Resonance in Medicine, 2021 . - 2021

Abstract

Extraction of prior knowledge basis function set for model-based perfusion reconstruction of the liver

Haseljić, Hana; Kulvait, Vojtech; Frysch, Robert; Wernecke, Thomas; Hensen, Bennet; Brüsch, Inga; Magdowski, Mathias; Wacker, Frank; Speck, Oliver; Rose, Georg

In: Konferenz: 5th Conference on Image-Guided Interventions, IGIC 2021, Magdeburg, 13-14 October 2021, 5th Conference on Image-Guided Interventions (IGIC) , 2021 - Magdeburg : [Otto-von-Guericke University Magdeburg] ; Hansen, Christian *1980-*, S. 11-12

Abstract

DdoS - dynamic dual-channel U-Net for improving deep learning based super-resolution of abdominal dynamic MRI

Sarasaen, Chompunuch; Chatterjee, Soumick; Nürnberger, Andreas; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg : Springer, Bd. 34 (2021), Heft Suppl. 1, S. S44, Artikel S6.O3

Abstract

Towards an energy monitoring system for an MRI hybrid RF ablation system

Shaik, Nashwa; Gerlach, Thomas; Hubmann, Joris; Pannicke, Enrico; Prier, Marcus; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: Konferenz: 5th Conference on Image-Guided Interventions, IGIC 2021, Magdeburg, 13-14 October 2021, 5th Conference on Image-Guided Interventions (IGIC) , 2021 - Magdeburg : [Otto-von-Guericke University Magdeburg] ; Hansen, Christian *1980-*, S. 77-78

Abstract

An Ex-Vivo study of an MRI hybrid ablation system

Gerlach, Thomas; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 55; 4950

Abstract

High resolution time-of-flight angiography of the pial arterial vasculature of the human brain in vivo

Bollmann, S.; Mattern, Hendrik; Bernier, M.; Robinson, S. R.; Park, D.; Speck, Oliver; Polimeni, J. R.

In: 12th Scientific Symposium on Clinical Needs, Research Promises and Technical Solutions - Berlin, 2021 . - 2021

Abstract

Electromagnetic simulations of different electrode shapes for an MRI hybrid ablation system

Mitra, Mishuk; Gerlach, Thomas; Kowal, Robert; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 59-60

Abstract

Proton resonance frequency-based 3D magnetic resonance thermometry using a stack of stars sequence for monitoring of hepatic microwave ablation

Meyer zu Hartlage, Karen; Hensen, Bennet; Gerlach, Thomas; Pannicke, Enrico; Speck, Oliver; Gutberlet, Marcel; Wacker, Frank

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 19-20

Abstract

Offcenter MRI-thermometry

Seibt, Janis; Pannicke, Enrico; Speck, Oliver

In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 15-16

Abstract

Stand-alone hardware SAR monitor based on low cost electronic standard components

Prier, Marcus; Hubmann, Max Joris; Pannicke, Enrico; Speck, Oliver

In: ISMRM & SMRT Annual Meeting and Exhibition$an online experience : 15-20 May 2021 - Concord, CA: International Society for Magnetic Resonance in Medicine, 2021 . - 2021

Book chapter

Upgraded W-Net with attention gates and its application in unsupervised 3D liver segmentation

Mitta, Dhanunjaya; Chatterjee, Soumick; Speck, Oliver; Nürnberger, Andreas

In: Proceedings of the 10th International Conference on Pattern Recognition Applications and Methods. Volume 1: February 4-6, 2021 - [Setúbal]: SCITEPRESS - Science and Technology Publications, Lda.; Marsico, Maria . - 2021, S. 488-494

Book chapter

ShuffleUNet - super resolution of diffusion-weighted MRIs using deep learning

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Mushunuri, Raghava Vinaykanth; Podishetti, Ranadheer; Rao, Rajatha Nagaraja; Gopinath, Geetha Doddapaneni; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: 29th European Signal Processing Conference (EUSIPCO 2021) - [Piscataway, NJ]: IEEE . - 2021

Book chapter

Analytical model of a split-coil for implementation of novel type of receive coil in magnetic resonance imaging

Pannicke, Enrico; Speck, Oliver; Vick, Ralf

In: 43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2021, S. 1522-1526

Book chapter

Distributed capacitors for MR-receive-coils - theory and method

Pannicke, Enrico; Speck, Oliver; Vick, Ralf

In: 43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2021, S. 1516-1521, 2020

Book chapter

3D-Printed floating cable traps for MRI guided microwave ablation

Ehses, Maik; Meyer zu Hartlage, Karen; Gerlach, Thomas; Löning Caballero, J. Joaquin; Reimert, Daniel; Pannicke, Enrico; Gutberlet, Marcel; Wacker, Frank; Speck, Oliver; Hensen, Bennet; Vick, Ralf

In: 43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2021, S. 1423-1426

Book chapter

Design of a system for magnetic-resonance-guided irreversible electroporation

Hubmann, Joris; Gerlach, Thomas; Pannicke, Enrico; Hensen, Bennet; Wacker, Frank; Speck, Oliver; Vick, Ralf

In: 43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2021, S. 1461-1465

Book chapter

Simulation of SAR induced heating in infants undergoing 1.5 T magnetic resonance imaging

Kowal, Robert; Prier, Marcus; Pannicke, Enrico; Vick, Ralf; Rose, Georg; Speck, Oliver

In: 43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2021, S. 3380-3384

Peer-reviewed journal article

Assessment of measurement precision in single-voxel spectroscopy at 7 T - toward minimal detectable changes of metabolite concentrations in the human brain in vivo

Riemann, Layla Tabea; Aigner, Christoph Stefan; Ellison, Stephen L. R.; Brühl, Rüdiger; Mekle, Ralf; Schmitter, Sebastian; Speck, Oliver; Rose, Georg; Ittermann, Bernd; Fillmer, Ariane

In: Magnetic resonance in medicine - New York, NY [u.a.] : Wiley-Liss, Bd. 87 (2022), Heft 3, S. 1119-1135

Peer-reviewed journal article

Rapid safety assessment and mitigation of radiofrequency induced implant heating using small root mean square sensors and the sensor matrix Q s

Silemek, Berk; Seifert, Frank; Petzold, Johannes; Hoffmann, Werner; Pfeiffer, Harald; Speck, Oliver; Rose, Georg; Ittermann, Bernd; Winter, Lukas

In: Magnetic resonance in medicine - New York, NY [u.a.] : Wiley-Liss, Bd. 87 (2021), Heft 1, S. 509-527

Peer-reviewed journal article

Perceived and mentally rotated contents are differentially represented in cortical depth of V1

Iamshchinina, Polina; Kaiser, Daniel; Yakupov, Renat; Haenelt, Daniel; Sciarra, Alessandro; Mattern, Hendrik; Lüsebrink-Rindsland, Jann Falk Silvester; Düzel, Emrah; Speck, Oliver; Weiskopf, Nikolaus; Cichy, Radoslaw Martin

In: Communications biology - London: Springer Nature, 2018, Bd. 4 (2021), insges. 8 S.

Peer-reviewed journal article

Publisher correction: Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions

Kaiser, Luca F.; Gruendler, Theo O. J.; Speck, Oliver; Luettgau, Lennart; Jocham, Gerhard

In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 12 (2021), insges. 2 S.

Peer-reviewed journal article

Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions

Kaiser, Luca F.; Gruendler, Theo O. J.; Speck, Oliver; Luettgau, Lennart; Jocham, Gerhard

In: Nature Communications - [London]: Nature Publishing Group UK, Bd. 12 (2021), insges. 11 S.

Peer-reviewed journal article

The traveling heads 2.0 - multicenter reproducibility of quantitative imaging methods at 7 tesla

Voelker, Maximilian N.; Kraff, Oliver; Görke, Steffen; Laun, Frederik B.; Hanspach, Jannis; Pine, Kerrin J.; Ehses, Philipp; Zaiss, Moritz; Liebert, Andrzej; Straub, Sina; Eckstein, Korbinian; Robinson, Simon; Nagel, Armin N.; Stefanescu, Maria R.; Wollrab, Astrid; Klix, Sabrina; Felder, Jörg; Hock, Michael; Bosch, Dario; Weiskopf, Nikolaus; Speck, Oliver; Ladd, Mark E.; Quick, Harald H.

In: NeuroImage - Orlando, Fla.: Academic Press, Bd. 232 (2021), S. 1-14, insges. 14 S.

Peer-reviewed journal article

Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance

Düzel, Emrah; Costagli, Mauro; Donatelli, Graziella; Speck, Oliver; Cosottini, Mirco

In: 2021, vorhttps://eurradiolexp.springeropen.com/articles/10.1186/s41747-021-00221-5

Peer-reviewed journal article

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimers disease

Franzmeier, Nicolai; Ren, Jinyi; Damm, Alexander; Monté-Rubio, Gemma; Boada, Mercè; Ruiz, Agustín; Ramírez, Alfredo; Jessen, Frank; Düzel, Emrah; Rodríguez Gómez, Octavio; Benzinger, Tammie; Goate, Alison; Karch, Celeste M.; Fagan, Anne M.; McDade, Eric; Buerger, Katharina; Levin, Johannes; Duering, Marco; Dichgans, Martin; Suárez-Calvet, Marc; Haass, Christian; Gordon, Brian A.; Lim, Yen Ying; Masters, Colin L.; Janowitz, Daniel; Catak, Cihan; Wolfsgruber, Steffen; Wagner, Michael; Milz, Esther; Moreno-Grau, Sonia; Teipel, Stefan; Grothe, Michel J.; Kilimann, Ingo; Rossor, Martin; Fox, Nick; Laske, Christoph; Chhatwal, Jasmeer; Falkai, Peter; Perneczky, Robert; Lee, Jae-Hong; Spottke, Annika; Boecker, Henning; Brosseron, Frederic; Fliessbach, Klaus; Heneka, Michael Thomas; Nestor, Peter; Peters, Oliver Hubertus; Fuentes, Manuel; Menne, Felix; Priller, Josef; Spruth, Eike J.; Franke, Christiana; Schneider, Anja; Westerteicher, Christine; Speck, Oliver; Wiltfang, Jens; Bartels, Claudia; Araque Caballero, Miguel Ángel; Metzger, Coraline Danielle; Bittner, Daniel Markus; Salloway, Stephen; Danek, Adrian; Hassenstab, Jason; Yakushev, Igor; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Ewers, Michael

In: Molecular psychiatry - London: Macmillan, Bd. 26 (2021), 2, S. 614-628

Peer-reviewed journal article

Fine-tuning deep learning model parameters for improved super-resolution of dynamic MRI with prior-knowledge

Sarasaen, Chompunuch; Chatterjee, Soumick; Breitkopf, Mario; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: Artificial intelligence in medicine - Amsterdam [u.a.] : Elsevier Science, Bd. 121 (2021), Artikel 102196

Peer-reviewed journal article

Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance

Düzel, Emrah; Costagli, Mauro; Donatelli, Graziella; Speck, Oliver; Cosottini, Mirco

In: European radiology experimental - [Cham] : Springer International Publishing, Bd. 5 (2021), Artikel 36, insges. 17 S.

Peer-reviewed journal article

Chemical shift-based prospective kspace anonymization

Mattern, Hendrik; Knoll, Martin; Lüsebrink-Rindsland, Jann Falk Silvester; Speck, Oliver

In: Magnetic resonance in medicine - New York, NY [u.a.]: Wiley-Liss, 1984, Bd. 85 (2021), 2, S. 962-969

Peer-reviewed journal article

CHAOS Challenge - combined (CT-MR) healthy abdominal organ segmentation

Kavur, A. Emre; Gezer, N. Sinem; Barış, Mustafa; Aslan, Sinem; Conze, Pierre-Henri; Groza, Vladimir; Pham, Duc Duy; Chatterjee, Soumick; Ernst, Philipp; Özkan, Savaş; Baydar, Bora; Lachinov, Dmitry; Han, Shuo; Pauli, Josef; Isensee, Fabian; Perkonigg, Matthias; Sathish, Rachana; Rajan, Ronnie; Sheet, Debdoot; Dovletov, Gurbandurdy; Speck, Oliver; Nürnberger, Andreas; Maier-Hein, Klaus H.; Bozdağı Akar, Gözde; Ünal, Gözde; Dicle, Oğuz; Selver, M. Alper

In: Medical image analysis - Amsterdam [u.a.]: Elsevier Science, Volume 69(2021), article 101950

Peer-reviewed journal article

Detection of cerebral microbleeds with venous connection at 7-Tesla MRI

Rotta, Johanna; Perosa, Valentina; Yakupov, Renat; Kuijf, Hugo J.; Schreiber, Frank; Dobisch, Laura; Oltmer, Jan; Assmann, Anne; Speck, Oliver; Heinze, Hans-Jochen; Acosta-Cabronero, Julio; Düzel, Emrah; Schreiber, Stefanie

In: Neurology - Philadelphia, Pa. : Wolters Kluwer, Bd. 96 (2021), Heft 16, S. e2048-e2057

Peer-reviewed journal article

Hemodynamic data assimilation in a subject-specific circle of Willis geometry

Gaidzik, Franziska; Pathiraja, Sahani; Saalfeld, Sylvia; Stucht, Daniel; Speck, Oliver; Thévenin, Dominique; Janiga, Gábor

In: Clinical neuroradiology - München: Urban & Vogel, 2006, Bd. 31 (2021), 3, S. 643-651

Peer-reviewed journal article

Comprehensive ultrahigh resolution whole brain in vivo MRI dataset as a human phantom

Lüsebrink-Rindsland, Jann Falk Silvester; Mattern, Hendrik; Yakupov, Renat; Acosta-Cabronero, Julio; Ashtarayeh, Mohammad; Oeltze-Jafra, Steffen; Speck, Oliver

In: Scientific data - London : Nature Publ. Group, Bd. 8 (2021), Artikel 138, insges. 13 S.

Dissertation

Empfangsspulen für bildgeführte Eingriffe mittels Magnetresonanztomographie

Pannicke, Enrico; Vick, Ralf; Speck, Oliver

In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektrotechnik und Informationstechnik 2021, 1 Online-Ressource (ii, 208 Seiten, 115,86 MB) - (Res electricae Magdeburgenses; Band 85) [Literaturverzeichnis: Seite 187-197]

Dissertation

Data-driven beam hardening correction for cone beam computed tomography

Abdurahman, Shiras; Rose, Georg; Speck, Oliver

In: Magdeburg: Universitätsbibliothek, 2021, 1 Online-Ressource (xvii, 125 Seiten, 14,04 MB), Illustrationen

Article in conference proceedings

Resolving to super resolution multi-dimensional diffusion imaging (Super-MUDI)

Nath, Vishwesh; Pizzolato, Marco; Palombo, Marco; Gyori, Noemi; Schilling, Kurt; Hansen, Colin; Yang, Qi; Kanakaraj, Praitayini; Landman, Bennett; Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Oeltze-Jafra, Steffen; Nürnberger, Andreas; Speck, Oliver; Pieciak, Tomasz; Baranek, Marcin; Bartocha, Kamil; Ciupek, Dominika; Bogusz, Fabian; Hamidinekoo, Azam; Afzali, Maryam; Lin, Harry; Alexander, Danny C.; Lan, Haoyu; Sepehrband, Farshid; Liang, Zifei; Wu, Tung-Yeh; Su, Ching-Wei; Wu, Qian-Hua; Liu, Zi-You; Chao, Yi-Ping; Albay, Enes; Unal, Gozde; Pylypenko, Dmytro; Ye, Xinyu; Zhang, Fan; Hutter, Jana

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Article in conference proceedings

ReconResNet: regularised residual learning for MR image reconstruction of undersampled cartesian and radial data

Chatterjee, Soumick; Breitkopf, Mario; Sarasaen, Chompunuch; Yassin, Hadya; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: Medical Imaging with Deep Learning - OpenReview.net . - 2021, insges. 3 S.

Article in conference proceedings

Going beyond the image space - undersampled MRI reconstruction directly in the k-space using a complex valued residual neural network

Chatterjee, Soumick; Sarasaen, Chompunuch; Sciarra, Alessandro; Breitkopf, Mario; Oeltze-Jafra, Steffen; Nürnberger, Andreas; Speck, Oliver

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Article in conference proceedings

A comparative study of deep learning based deformable image registration techniques

Chatterjee, Soumick; Bajaj, Himanshi; Shashidhar, Suraj; Busnur Indushekar, Sanjeeth; Simon, Steve; Siddiquee, Istiyak; Nandish, B. S.; Speck, Oliver; Nürnberger, Andreas

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Article in conference proceedings

Unsupervised reconstruction based anomaly detection using a Variational Auto Encoder

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Agrawal, Shubham; Tummala, Pavan; Setlur, Disha Kishore; Kalra, Aman; Jauhari, Aishwarya; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Article in conference proceedings

Fine-tuning deep learning model parameters for improved super-resolution of dynamic MRI with prior-knowledge

Sarasaen, Chompunuch; Chatterjee, Soumick; Saad, Fatima; Breitkopf, Mario; Nürnberger, Andreas; Speck, Oliver

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Article in conference proceedings

Prior-aided volume of interest CBCT image reconstruction

Punzet, Daniel; Frysch, Robert; Speck, Oliver; Rose, Georg

In: Proceedings of the 16th Virtual International Meeting on Fully 3D Image Reconstruction in Radiology and Nuclear Medicine$xhEditors: Georg Schramm, Ahmadreza Rezaei, Kris Thielemans and Johan Nuyts - arXiv ; Schramm, Georg . - 2021, S. 76-80

Article in conference proceedings

DS6, deformation-aware semi-supervised learning - application to small vessel segmentation with noisy training data

Chatterjee, Soumick; Prabhu, Kartik; Pattadkal, Mahantesh; Bortsova, Gerda; Sarasaen, Chompunuch; Dubost, Florian; Mattern, Hendrik; Bruijne, Marleen; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: Medical Imaging with Deep Learning, MIDL 2021, Lübeck, Germany, 7. Juli 2021, Medical Imaging with Deep Learning - OpenReview.net . - 2021, insges. 3 S.

Article in conference proceedings

Interpretability techniques for deep learning based segmentation models

Chatterjee, Soumick; Das, Arnab; Mandal, Chirag; Mukhopadhyay, Budhaditya; Vipinraj Bhandari, Manish Bhandari; Shukla, Aniruddh; Speck, Oliver; Nürnberger, Andreas

In: Kongress: 2021 ISMRM & SMRT Annual Meeting & Exhibition, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2021

Non-peer-reviewed journal article

TorchEsegeta - framework for interpretability and explainability of image-based deep learning models

Chatterjee, Soumick; Das, Arnab; Mandal, Chirag; Mukhopadhyay, Budhaditya; Vipinraj, Manish; Shukla, Aniruddh; Rao, Rajatha Nagaraja; Sarasaen, Chompunuch; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.]: Arxiv.org . - 2021, insges. 15 S.

Non-peer-reviewed journal article

ShuffleUNet: super resolution of diffusion-weighted MRIs using deep learning

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Mushunuri, Raghava Vinaykanth; Podishetti, Ranadheer; Rao, Rajatha Nagaraja; Gopinath, Geetha Doddapaneni; Oeltze-Jafra, Steffen; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.] : Arxiv.org . - 2021, S. 1-5, Artikel 2102.12898

Non-peer-reviewed journal article

Sinogram upsampling using primal-dual UNet for undersampled CT and radial MRI reconstruction

Ernst, Philipp; Chatterjee, Soumick; Rose, Georg; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.]: Arxiv.org . - 2021, insges. 20 S.

Non-peer-reviewed journal article

Classification of brain tumours in MR images using deep spatiospatial models

Chatterjee, Soumick; Nizamani, Faraz Ahmed; Nürnberger, Andreas; Speck, Oliver

In: De.arxiv.org - [S.l.]: Arxiv.org . - 2021, insges. 12 S.

Non-peer-reviewed journal article

ReconResNet: regularised residual learning for MR image reconstruction of undersampled cartesian and radial data

Chatterjee, Soumick; Breitkopf, Mario; Sarasaen, Chompunuch; Yassin, Hadya; Podishetti, Ranadheer; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: De.arxiv.org - [S.l.]: Arxiv.org . - 2021, S. 1-15

2020

Abstract

Specific absorption rate in a dedicated birdcage coil for nenoatal MRI

Kowal, Robert; Prier, Marcus; Pannicke, Enrico; Gerlach, Thomas; Röll, Stefan; Vick, Ralf; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg: Springer, 1993, Volume 33(2020), Suppl. 1, Seite S40

Abstract

Epipolar-constrained optical flow triangulation for the interior problem in CBCT

Punzet, Daniel; Frysch, Robert; Khosroshahi, Elnaz; Beuing, Oliver; Speck, Oliver; Rose, Georg

In: Online-programm - IEEE, 2020, 2020, Poster panel: 179

Abstract

Power control for an MRI ablation hybrid system

Gerlach, Thomas; Alpers, Julian; Pannicke, Enrico; Hansen, Christian; Speck, Oliver; Vick, Ralf

In: ISMRM 28th annual ISMRM virtual conference & exhibition, 08. - 14. August 2020/ ISMRM Annual Meeting & Exhibition, 2020, 2020, Poster 4217

Abstract

Perceived and mentally rotated contents are differentially represented in cortical layers of V1

Iamshchinina, Polina; Kaiser, Daniel; Yakupov, Renat; Haenelt, Daniel; Sciarra, Alessandro; Mattern, Hendrik; Duezel, Emrah; Speck, Oliver; Weiskopf, Nikolaus; Martin Cichy, Radoslaw

In: Journal of vision: an ARVO journal ; JOV - Rockville, Md.: ARVO, 2001, Bd. 20.2020, 11, S. 766[Meeting: 20th Annual Meeting of the Vision Science Society]

Abstract

A high fMRI activation deviation score is linked to worse clinical phenotype and Aß42/40 positivity

Billette, Ornella; Ziegler, Gabriel; Schütze, Hartmut; Schott, Björn H.; Richter, Anni; Cardenas-Blanco, Arturo; Metzger, Coraline Danielle; Bittner, Daniel Markus; Glanz, Wenzel; Spottke, Annika E.; Brosseron, Frederic; Buerger, Katharina; Fließbach, Klaus; Heneka, Michael Thomas; Laske, Christoph; Nestor, Peter J.; Priller, Josef; Schneider, Anja; Speck, Oliver; Teipel, Stefan; Peters, Oliver Hubertus; Wiltfang, Jens; Perneczky, Robert; Wagner, Michael; Jessen, Frank; Maass, Anne; Düzel, Emrah

In: Konferenz: Alzheimer's Association International Conference, virtual, 27. - 31. July 2020, Alzheimer's Association International Conference - Alzheimer's Association . - 2020, insges. 2 S.

Abstract

From PCB to simulation - a workflow instruction for designing birdcage models from production data

Kowal, Robert; Prier, Marcus; Pannicke, Enrico; Röll, Stefan; Vick, Ralf; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg: Springer, 1993, Volume 33(2020), Suppl. 1, Seite S163-164

Abstract

Super-resolution with conditional-GAN for MR brain images

Sciarra, Alessandro; Dünnwald, Max; Mattern, Hendrik; Speck, Oliver; Oeltze-Jafra, Steffen

In: ISMRM 28th annual ISMRM virtual conference & exhibition, 08. - 14. August 2020: SMRT 29th annual meeting, Concord, CA./ ISMRM Annual Meeting & Exhibition, 2020, 2020, Poster 3540[ISMRM 28th annual ISMRM virtual conference & exhibition, virtual, 08. - 14. August 2020]

Abstract

Contrast prediction-based regularization for iterative reconstructions (PROSIT)

Mattern, Hendrik; Sciarra, Alessandro; Dünnwald, Max; Chatterjee, Soumick; Müller, Ursula; Oeltze-Jafra, Steffen; Speck, Oliver

In: ISMRM 28th annual ISMRM virtual conference & exhibition, virtual, 08. - 14. August 2020, ISMRM 28th annual ISMRM virtual conference & exhibition, 08. - 14. August 2020 / ISMRM Annual Meeting & Exhibition , 2020 - 2020, Poster 3462

Abstract

Remotely controllable phantom rotation device for cross-calibration at 7T

Mattern, Hendrik; Odenbach, Robert; Thoma, Niklas; Godenschweger, Frank; Speck, Oliver

In: ISMRM 28th annual ISMRM virtual conference & exhibition, 08. - 14. August 2020: SMRT 29th annual meeting, Concord, CA./ ISMRM Annual Meeting & Exhibition, 2020, 2020, Poster 3372[ISMRM 28th annual ISMRM virtual conference & exhibition, virtual, 08. - 14. August 2020]

Abstract

Vessel distance mapping

Mattern, Hendrik; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine: (MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Heidelberg: Springer, 1993, Volume 33(2020), Suppl. 1, Seite S195[Meeting: ESMRMB 2020 online, September 30 - October 2, 2020]

Abstract

Chemical sHift bAsed pRospectIve k-Space anonyMizAtion (CHARISMA)

Mattern, Hendrik; Knoll, Martin; Lüsebrink, Falk; Speck, Oliver

In: ISMRM 28th annual ISMRM virtual conference & exhibition, 08. - 14. August 2020: SMRT 29th annual meeting, Concord, CA./ ISMRM Annual Meeting & Exhibition, 2020, 2020, Poster 1049[ISMRM 28th annual ISMRM virtual conference & exhibition, virtual, 08. - 14. August 2020]

Abstract

Classification of motion corrupted brain MR images using deep learning techniques

Sciarra, Alessandro; Dünnwald, Max; Chatterjee, Soumick; Speck, Oliver; Oeltze-Jafra, Steffen

In: Magnetic resonance materials in physics, biology and medicine - Heidelberg: Springer, 1993, Bd. 33 (2020), S. S33

Abstract

Hippocampal volumetric variability is associated with memory in subjective cognitive decline

Ziegler, Gabriel; Heinzinger, Nils; Metzger, Coraline Danielle; Yakupov, Renat; Bittner, Daniel Markus; Glanz, Wenzel; Spottke, Annika; Brosseron, Frederic; Bürger, Katharina; Fließbach, Klaus; Heneka, Michael Thomas; Laske, Christoph; Nestor, Peter J.; Peters, Oliver Hubertus; Priller, Josef; Ramírez, Alfredo; Schneider, Anja; Speck, Oliver; Teipel, Stefan; Wiltfang, Jens; Wagner, Michael; Düzel, Emrah; Jessen, Frank

In: Alzheimer's and dementia - Hoboken, NJ: Wiley, 2005, Vol. 16.2020, Suppl. 5, e043527, 3 Seiten

Book chapter

3D-localization of anatomic structures in tomographic images from optical flow of projection images

Punzet, Daniel; Frysch, Robert; Beuing, Oliver; Speck, Oliver; Rose, Georg

In: Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, Bd. 11312 (2020), S. 654-659

Book chapter

Entropy-based SVM classifier for automatic detection of motion artifacts in clinical MRI

Preetha, Chandrakanth Jayachandran; Mattern, Hendrik; Juneja, Medha; Vogt, Johannes; Speck, Oliver; Hartkens, Thomas

In: Bildverarbeitung für die Medizin 2020 / Workshop Bildverarbeitung für die Medizin , 2020 , 1st ed. 2020. - Wiesbaden : Springer Fachmedien Wiesbaden ; Tolxdorff, Thomas, S. 107-112

Peer-reviewed journal article

Hippocampal vascular reserve associated with cognitive performance and hippocampal volume

Perosa, Valentina; Priester, Anastasia; Ziegler, Gabriel; Cardenas-Blanco, Arturo; Dobisch, Laura; Spallazzi, Marco; Assmann, Anne; Maass, Anne; Speck, Oliver; Oltmer, Jan; Heinze, Hans-Jochen; Schreiber, Stefanie; Düzel, Emrah

In: Brain - Oxford : Oxford Univ. Press, Bd. 143 (2020), Heft 2, S. 622-634

Peer-reviewed journal article

Fat navigators and Moiré phase tracking comparison for motion estimation and retrospective correction

Gretsch, Frédéric; Mattern, Hendrik; Gallichan, Daniel; Speck, Oliver

In: Magnetic resonance in medicine: MRM ; an official journal of the International Society for Magnetic Resonance in Medicine - New York, NY [u.a.]: Wiley-Liss, Bd. 83.2020, 1, S. 83-93

Peer-reviewed journal article

Phase-contrast MRI detection of ventricular shunt CSF flow - proof of principle

König, Rebecca E.; Stucht, Daniel; Baecke, Sebastian; Rashidi, Ali; Speck, Oliver; Sandalcioglu, I. Erol; Luchtmann, Michael

In: Journal of neuroimaging - Berlin [u.a.]: Wiley-Blackwell, 1991, Bd. 30 (2020), 6, S. 746-753

Peer-reviewed journal article

Triple visual hemifield maps in a case of optic chiasm hypoplasia

Ahmadi, Khazar; Fracasso, Alessio; Puzniak, Robert J.; Gouws, Andre D.; Yakupov, Renat; Speck, Oliver; Kaufmann, Joern; Pestilli, Franco; Dumoulin, Serge O.; Morland, Antony B.; Hoffmann, Michael

In: NeuroImage - Orlando, Fla. : Academic Press - Volume 215.2020, article 116822, insgesamt 13 Seiten

Peer-reviewed journal article

Contrast-enhancement in the wall of a cerebral fusiform aneurysm in neuroborreliosis at 7 T MRI

Perosa, Valentina; Bartels, Claudius; Godenschweger, Frank; Speck, Oliver; Heinze, Hans-Jochen; Vielhaber, Stefan; Schreiber, Stefanie

In: Journal of the neurological sciences - Amsterdam [u.a.] : Elsevier Science - Volume 418.2020, article 117112

Peer-reviewed journal article

Prominent white matter involvement in multiple system atrophy of cerebellar type

Faber, Jennifer; Giordano, Ilaria; Jiang, Xueyan; Kindler, Christine; Spottke, Annika; AcostaCabronero, Julio; Nestor, Peter J.; Wesenberg, Judith; Düzel, Emrah; Vielhaber, Stefan; Speck, Oliver; Dudešek, Ales; Kamm, Christoph; Scheef, Lukas; Klockgether, Thomas

In: Movement disorders - New York, NY : Wiley, Bd. 35 (2020), Heft 5, S. 816-824

Peer-reviewed journal article

Corrigendum - Hippocampal vascular reserve associated with cognitive performance and hippocampal volume

Perosa, Valentina; Priester, Anastasia; Ziegler, Gabriel; Cardenas-Blanco, Arturo; Dobisch, Laura; Spallazzi, Marco; Assmann, Anne; Maass, Anne; Speck, Oliver; Oltmer, Jan; Heinze, Hans-Jochen; Schreiber, Stefanie; Düzel, Emrah

In: Brain - Oxford : Oxford Univ. Press, Bd. 143 (2020), Heft 5, S. e43

Peer-reviewed journal article

Transorbital alternating current stimulation modifies BOLD activity in healthy subjects and in a stroke patient with hemianopia - a 7 Tesla fMRI feasibility study

Sabel, Bernhard A.; Abd Hamid, Aini Ismafairus Binti; Borrmann, Carolin; Speck, Oliver; Antal, Andrea

In: International journal of psychophysiology: official journal of the International Organization of Psychophysiology - Amsterdam [u.a.]: Elsevier Science, Bd. 154.2020, S. 80-92

Dissertation

Die Aufnahme ultrahochaufgelöster Magnetresonanztomographiedaten des menschlichen Gehirns in vivo und deren quantitative Analyse

Lüsebrink-Rindsland, Jann Falk Silvester; Speck, Oliver

In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2020, 144 Seiten [Literaturverzeichnis: Seite 115-131]

Article in conference proceedings

Evaluation of deep learning techniques for motion artifacts removal

Sciarra, Alessandro; Chatterjee, Soumick; Dünnwald, Max; Speck, Oliver; Oeltze-Jafra, Steffen

In: Konferenz: ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. . - 2020

Article in conference proceedings

Wavelet filtering of undersampled MRI using trainable wavelets and CNN

Chatterjee, Soumick; Putti, Praveen; Nürnberger, Andreas; Speck, Oliver

In: Kongress: ESMRMB 2020 Online Convergence Science & Education, September 30 - October 2, 2020, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2020

Article in conference proceedings

Retrospective motion correction of MR images using prior-assisted deep learning

Chatterjee, Soumick; Sciarra, Alessandro; Dünnwald, Max; Oeltze-Jafra, Steffen; Nürnberger, Andreas; Speck, Oliver

In: Konferenz: Medical Imaging Meets NeurIPS 2020, virtual, December 2020, ResearchGATE - Cambridge, Mass. : ResearchGATE Corp. - 2020, insgesamt 5 Seiten

Article in conference proceedings

Upgraded W-net with attention gates and its application in unsupervised 3D liver segmentation

Mitta, Dhanunjaya; Chatterjee, Soumick; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ICPRAM 2021, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2020

Article in conference proceedings

Super resolution of dynamic MRI using deep learning, enhanced by prior-knowledge

Sarasaen, Chompunuch; Chatterjee, Soumick; Nürnberger, Andreas; Speck, Oliver

In: Kongress: ESMRMB 2020 Online Convergence Science & Education, September 30 - October 2, 2020, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2020

Article in conference proceedings

Unsupervised learning for Abdominal MRI Segmentation using 3D Attention W-Net

Mitta, Dhanunjaya; Chatterjee, Soumick; Speck, Oliver; Nürnberger, Andreas

In: Konferenz: ISMRM & SMRT Virtual Conference & Exhibition, 08-14 August 2020, ResearchGATE - Cambridge, Mass.: ResearchGATE Corp. . - 2020

Non-peer-reviewed journal article

CHAOS challenge - combined (CT-MR) healthy abdominal organ segmentation

Kavur, A. Emre; Gezer, N. Sinem; Barış, Mustafa; Aslan, Sinem; Conze, Pierre-Henri; Groza, Vladimir; Pham, Duc Duy; Chatterjee, Soumick; Ernst, Philipp; Özkan, Savaş; Baydar, Bora; Lachinov, Dmitry; Han, Shuo; Pauli, Josef; Isensee, Fabian; Perkonigg, Matthias; Sathish, Rachana; Rajan, Ronnie; Sheet, Debdoot; Dovletov, Gurbandurdy; Speck, Oliver; Nürnberger, Andreas; Maier-Hein, Klaus H.; Akar, Gözde Bozdağı; Ünal, Gözde; Dicle, Oğuz; Selver, M. Alper.

In: De.arxiv.org - [S.l.]: Arxiv.org, 2020, article 2001.06535, insgesamt 19 Seiten

Non-peer-reviewed journal article

DS6: deformation-aware learning for small vessel segmentation with small, imperfectly labeled dataset

Chatterjee, Soumick; Prabhu, Kartik; Pattadkal, Mahantesh; Bortsova, Gerda; Dubost, Florian; Mattern, Hendrik; Bruijne, Marleen; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.]: Arxiv.org, 2020, article 2006.10802, insgesamt 13Seiten

Non-peer-reviewed journal article

Exploration of interpretability techniques for deep COVID-19 classification using chest X-ray images

Chatterjee, Soumick; Saad, Fatima; Sarasaen, Chompunuch; Ghosh, Suhita; Khatun, Rupali; Radeva, Petia; Rose, Georg; Stober, Sebastian; Speck, Oliver; Nürnberger, Andreas

In: De.arxiv.org - [S.l.]: Arxiv.org, 2020, article 2006.02570, insgesamt 16 Seiten

2019

Abstract

Hippocampal subfield segmentation and partial volume effects - reliability assessment

Cardenas-Blanco, Arturo; Chen, Y.; Valdes-Herrera, J. P.; Yakupov, Renat; Mattern, Hendrik; Sciarra, Alessandro; Berron, D.; Maaß, Anne; Speck, Oliver; Düzel, Emrah

In: Konferenz: 27th Annual Meeting of International Society of Magnetic Resonance in Medicine, ISMRM, Montreal, Canada, 11 - 16 May 2019, ISMRM 27th annual ISMRM meeting & exhibition, 11 - 16 May 2019 / ISMRM Annual Meeting & Exhibition , 2019

Abstract

The traveling heads 2.0 - reproducibility of quantitative imaging methods at 7 Tesla

Voelker, M.; Kraff, O.; Goerke, S.; Laun, F.; Pine, K.; Ehses, P.; Zaiss, M.; Liebert, A.; Eckstein, K.; Robinson, S.; Nagel, A.; Speck, Oliver; Ladd, M.; Quick, H.

In: ISMRM 27th annual ISMRM meeting & exhibition, 11 - 16 May 2019: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada / International Society for Magnetic Resonance in Medicine, International Society of Magnetic Resonance in Medicine, Section for Magnetic Resonance Technologists: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada/ ISMRM Annual Meeting & Exhibition, 2019 . - 2019[Konferenz: 27th Annual Meeting of International Society of Magnetic Resonance in Medicine, ISMRM, Montreal, Canada, 11 - 16 May 2019]

Abstract

GUFI safety training for ultra-high field MRI

Wollrab, Astrid; Kraff, Oliver; Speck, Oliver; Quick, Harald H.; Ladd, Mark E.

In: ISMRM Workshop on MR Safety Ensuring Safety from First Principles to Best Practices: University Medical Centre Utrecht, Utrecht, The Netherlands, 20-22 September 2019 : programm - ISMRM, 2019 . - 2019[Workshop: ISMRM Workshop on MR Safety Ensuring Safety from First Principles to Best Practices, Utrecht, 20-22 September 2019]

Abstract

Isotropic high-resolution DIADEM-VAT at UHF

Tung, Yi-Hang; In, Myung-Ho; Sciarra, Alessandro; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine: (MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Heidelberg: Springer, 1993, Volume 32, Supplement 1 (2019), Seite S72[Tagung: 36th Annual Scientific Meeting of European Society for Magnetic Resonance in Medicine and Biology, ESMRMB 2019, Rotterdam, NL, 3-5 October 2019]

Abstract

Generating breathing deformation model from low resolution 4D MRI

Sarasaen, Chompunuch; Chatterjee, Soumick; Breitkopf, Mario; Rose, Georg; Speck, Oliver

In: 4th Image-Guided Interventions Conference: digitalization in medicine : November 4th-5th 2019, UMM, Mannheim - Mannheim, 2019 . - 2019

Abstract

Konzeptstudie eines interventionellen Computertomographen

Sarasaen, Chompunuch; Chatterjee, Soumick; Breitkopf, Mario; Rose, Georg; Speck, Oliver

In: 4th Image-Guided Interventions Conference: digitalization in medicine : November 4th-5th 2019, UMM, Mannheim - Mannheim, 2019 . - 2019

Abstract

Beyond high resolution - denoising during image reconstruction to improve image quality

Lüsebrink-Rindsland, Jann Falk Silvester; Mattern, Hendrik; Oeltze-Jafra, Steffen; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine: (MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Heidelberg: Springer, 1993, Volume 32, Supplement 1 (2019), Seite S271[Tagung: 36th Annual Scientific Meeting of European Society for Magnetic Resonance in Medicine and Biology, ESMRMB 2019, Rotterdam, NL, 3-5 October 2019]

Abstract

Image reconstruction pipeline

Lüsebrink-Rindsland, Jann Falk Silvester; Mattern, Hendrik; Oeltze-Jafra, Steffen; Speck, Oliver

In: Magnetic resonance materials in physics, biology and medicine: (MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Heidelberg: Springer, 1993, Volume 32, Supplement 1 (2019), Seite S419[Tagung: 36th Annual Scientific Meeting of European Society for Magnetic Resonance in Medicine and Biology, ESMRMB 2019, Rotterdam, NL, 3-5 October 2019]

Abstract

High resolution imaging of the arterial and venous vasculature in deep gray matter

Mattern, Hendrik; Acosta-Cabronero, A.; Speck, Oliver

In: ISMRM 27th annual ISMRM meeting & exhibition, 11 - 16 May 2019: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada / International Society for Magnetic Resonance in Medicine, International Society of Magnetic Resonance in Medicine, Section for Magnetic Resonance Technologists: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada/ ISMRM Annual Meeting & Exhibition[Konferenz: 27th Annual Meeting of International Society of Magnetic Resonance in Medicine, ISMRM, Montreal, Canada, 11 - 16 May 2019]

Abstract

Direct comparison of fat navigators and Moiré phase tracking for retrospective brain motion correction at 7T

Gretsch, Frédéric; Mattern, Hendrik; Gallichan, Daniel; Speck, Oliver

In: ISMRM 27th annual ISMRM meeting & exhibition, 11 - 16 May 2019: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada / International Society for Magnetic Resonance in Medicine, International Society of Magnetic Resonance in Medicine, Section for Magnetic Resonance Technologists: SMRT 28th annual meeting, 10 13. May 2019, Montréal : QC, Canada/ ISMRM Annual Meeting & Exhibition[Konferenz: 27th Annual Meeting of International Society of Magnetic Resonance in Medicine, ISMRM, Montreal, Canada, 11 - 16 May 2019]

Abstract

Comparison between the usage of same and different variable density undersampling patterns for Deep Learning based MRI Reconstruction

Chatterjee, Soumick; Breitkopf, Mario; Sarasaen, Chompunuch; Rose, Georg; Nürnberger, Andreas; Speck, Oliver

In: 4th Image-Guided Interventions Conference: digitalization in medicine : November 4th-5th 2019, UMM, Mannheim - Mannheim, 2019 . - 2019

Abstract

Estimating the patient extent from truncated CBCT projections

Punzet, Daniel; Frysch, Robert; Beuing, Oliver; Speck, Oliver; Rose, Georg

In: 4th Image-Guided Interventions Conference: digitalization in medicine : November 4th-5th 2019, UMM, Mannheim - Mannheim, 2019 . - 2019, S. 40

Abstract

MR thermometry with an ablation electrode

Gerlach, Thomas; Pannicke, Enrico; Speck, Oliver; Vick, Ralf

In: 4th Image-Guided Interventions Conference: digitalization in medicine : November 4th-5th 2019, UMM, Mannheim - Mannheim, 2019 . - 2019, insges. 2 S.

Abstract

Ventral anterior cingulate glutamatergic disbalance in major depressive disorder depends on symptom severity

Colic, Lejla; Duering, Felicia; Denzel, Dominik; Demenescu, Liliana Ramona; Lord, Anton; Martens, Louise; Lison, Sarah; Frommer, Jörg; Vogel, Matthias; Kaufmann, Jörn; Speck, Oliver; Li, Meng; Walter, Martin

In: European neuropsychopharmacology: ENP ; the journal of the European College of Neuropsychopharmacology - Amsterdam: Elsevier, Bd. 29.2019, Supplement 2, P.3.27, Seite S699-S700

Book chapter

Breathing deformation model - application to multi-resolution abdominal MRI

Sarasaen, Chompunuch; Chatterjee, Soumick; Breitkopf, Mario; Iuso, Domenico; Rose, Georg; Speck, Oliver

In: Konferenz: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Berlin, Germany, 23-27 July 2019, Biomedical engineering ranging from wellness to intensive care/ IEEE Engineering in Medicine and Biology Society - [Piscataway, NJ]: IEEE; Barbieri, Ricardo . - 2019, S. 2769-2772

Book chapter

Breathing deformation model - application to multi-resolution abdominal MRI

Sarasaen, Chompunuch; Chatterjee, Soumick; Breitkopf, Mario; Iuso, Domenico; Rose, Georg; Speck, Oliver

In: Konferenz: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Berlin, Germany, 23-27 July 2019, 41st Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) - [Piscataway, NJ]: IEEE . - 2019

Book chapter

Setup of an ablation magnetic resonance imaging hybrid system - using MR imaging sequences to destroy tissue

Gerlach, Thomas; Pannicke, Enrico; Prier, Marcus; Seifert, Frank; Speck, Oliver; Vick, Ralf

In: Konferenz: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Berlin, Germany, 23-27 July 2019, Biomedical engineering ranging from wellness to intensive care/ IEEE Engineering in Medicine and Biology Society - [Piscataway, NJ]: IEEE; Barbieri, Ricardo . - 2019, S. 2508-2512

Peer-reviewed journal article

Rostral anterior cingulate glutamine/glutamate disbalance in major depressive disorder depends on symptom severity

Colic, Lejla; Düring, Felicia; Denzel, Dominik; Demenescu, Liliana Ramona; Lord, Anton R.; Martens, Louise; Lison, Sarah; Frommer, Jörg; Vogel, Matthias; Kaufmann, Joern; Speck, Oliver; Li, Meng; Walter, Martin

In: Biological psychiatry - Amsterdam [u.a.]: Elsevier Inc., Bd. 4.2019, 12, S. 1049-1058

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